The goal of this project is to develop simple and reliable biochemical tests which can be used to identify individuals at risk for alcoholism, and/or to accurately indicate recent alcohol abuse. in phase i, the feasibility of using platelet enzymes as such markers will be assessed. our preliminary… More

The application's long-term objective is to develop a more effective, safe, relatively long-term barrier contraceptive device. development of the proposed device will have significant impact on effective control of overpopulation and reduction of abortions secondary to unwanted pregnancies. the… More

Chronic ethanol ingestion results in neurodegeneration with loss of neurons, glial proliferation anventricular and subarachnoid space. Work from our laboratories has demonstrated that chronic ethanolanimals produces an up-regulation of the excitatory N-methyl-D-aspartate (NMDA) subtype of… More

DESCRIPTION (provided by applicant): Alcohol dependence and hazardous levels of ethanol ingestion are under-diagnosed and under-reported. Significant effort has been expended to develop biological markers (diagnostics) for monitoring levels and/or recency of alcohol use (state markers) and markers… More

DESCRIPTION (provided by applicant): Alcohol dependence and hazardous levels of ethanol ingestion are under-diagnosed and under-reported. Significant effort has been expended to develop biological markers (diagnostics) for monitoring levels and/or recency of alcohol use (state markers) and markers… More

DESCRIPTION (provided by applicant): The goal of this SBIR application is to demonstrate the feasibility of a global approach to screen for disease specific monoclonal antibodies (mAbs) to low level proteins for the discovery and validation of biomarkers o f alcohol-induced liver damage. The… More