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THE AIM OF THIS PROJECT IS TO DEMONSTRATE AN IMMUNOMETRIC ASSAY FOR HEPATITIS B…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
2938
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
2938
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
London Diagnostics Inc
10300 Valley View Rd Suite 107 Eden Prairie, MN 55344
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: THE AIM OF THIS PROJECT IS TO DEMONSTRATE AN IMMUNOMETRIC ASSAY FOR HEPATITIS B SURFACE ANTIGEN (HBSAG) USING ACRIDINIUM ESTERS AS A CHEMILUMINESCENT LABEL.
Agency: HHS
Contract: N/A
Award Amount: $46,118.00
 

Abstract:

THE AIM OF THIS PROJECT IS TO DEMONSTRATE AN IMMUNOMETRIC ASSAY FOR HEPATITIS B SURFACE ANTIGEN (HBSAG) USING ACRIDINIUM ESTERS AS A CHEMILUMINESCENT LABEL. THIS WILL LEAD TO A TECHNIQUE FOR THE DETECTION OF VIRAL ANTIGENS THAT REQUIRES EXQUISITE SENSITIVITY, BY A METHOD WHICH IS SIMPLER, SAFER, AND CHEAPER THAN CONVENTIONAL METHODS. MONOCLONAL ANTIBODIES TO HBSAG WILL BE COVALENTLY LABELED WITH AN ACRIDINIUM ESTER TO A HIGH SPECIFIC LUMINESCENCE ACTIVITY. THESE WILL THEN BE USED IN COMMERCIAL KITS TO DEVELOP A SENSITIVE CHEMILUMINESCENCE ASSAY. OTHER ACRIDINIUM ESTERS WILL ALSO BE TESTED IN THESE ASSAYS. AFTER ASSAY OPTIMIZATION, THE CHEMILUMINESCENCE ASSAY WILL BE COMPARED WITH IMMUNORADIOMETRIC ASSAYS AND DETECTION LIMITS USING HBSAG PANELS DETERMINED. THE RESEARCH IS EXPECTED TO PROVIDE AN HBSAG ASSAY WITH LOWER DETECTION LIMITS, USING STABLE REAGENTS. THE ASSAY SHOULD BE SAFER, SIMPLER, AND CHEAPER THAN COMMERCIAL ASSAYS, WITH A GREATER SLOPE AIDING THE PRECISION OF DETECTION. THIS WORK WOULD LEAD TO PHASE II PRODUCTION OF ANTIBODIES, IMPROVED CHEMILUMINESCENT COMPOUNDS, ASSAY CONFIGURATIONS, PROTOTYPE INSTRUMENT DESIGN AND DEVELOPMENT, AND CLINICAL TRIALS. THE MULTIMILLION DOLLAR VIRAL ANTIGEN IMMUNOASSAY MARKET WOULD READILY ACCEPT A CHEMILUMINESCENCE ASSAY WITH THE ADVANTAGES THE TECHNOLOGY HAS TO OFFER.

Principal Investigator:

A. patel
PRINCIPAL INVESTIGATOR
6129333616

Business Contact:

Small Business Information at Submission:

London Diagnostics, Inc.,
10701 Red Circle Drive Minnetonka, MN 55343

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No