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NEW LABELING REAGENTS FOR GENETIC ANALYSIS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
59948
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
CA096451
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MARKER GENE TECHNOLOGIES, INC
1850 MILLRACE DRIVE 1850 MILLRACE DRIVE EUGENE, OR 97403 1992
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: Yes
 
Phase 1
Fiscal Year: 2002
Title: NEW LABELING REAGENTS FOR GENETIC ANALYSIS
Agency: HHS
Contract: 1R43CA096451-01
Award Amount: $99,982.00
 

Abstract:

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project aims to investigate the feasibility of developing new, sensitive, accurate, and reliable detection methods for genomic DNA or RNA samples that are essential for genomic microarray analysis. If successful, the proposed research will help provide breakthroughs needed to advance the promising medical uses of genomic analysis to determine the pattern of gene expression in live cell assays. In Phase I of this project, Marker Gene Technologies proposes to establish the feasibility of the technology by preparing new labeling reagents and systems capable of directly modifying DNA or RNA oligomers for ultrasensitive fluorescence or chemiluminescent detection. These labeling reagents will be assayed in vitro for their ability to monitor gene expression events in response to biological effects on cell function and to monitor the change in gene expression upon application of drugs and bioactive compounds in a cell-specific manner. In Phase II, these and additional detection reagents and methods will be further tested in a variety of pre-clinical applications for genomic expression analysis combined with drug application. PROPOSED COMMERCIAL APPLICATION: The success of this project opens up enormous commercial possibilities in the fields of medical intervention in genetic diseases, genetic screening of new proteins and drugs in cell-culture systems, and new anti-bacterial and anti-viral agent discovery. In addition, it contributes new information and techniques for basic cell-biology research, and the labeling reagents and techniques produced can be marketed for these research and commercial uses.

Principal Investigator:

John J. Naleway
5413423760
JNALEWAY@OREGON.UOREGON.EDU

Business Contact:

Alisa Naleway
5033441624
ALISANALEWAY@HOTMAIL.COM
Small Business Information at Submission:

MARKER GENE TECHNOLOGIES
MARKER GENE TECHNOLOGIES 3247 LINCOLN ST EUGENE, OR 97405

EIN/Tax ID: 931228900
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No