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LUCIFERASE DIRECTED SUBSTRATES FOR CELL REGULATION

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
61020
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
GM065670
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MARKER GENE TECHNOLOGIES, INC
1850 MILLRACE DRIVE 1850 MILLRACE DRIVE EUGENE, OR 97403 1992
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: Yes
 
Phase 1
Fiscal Year: 2002
Title: LUCIFERASE DIRECTED SUBSTRATES FOR CELL REGULATION
Agency: HHS
Contract: 1R43GM065670-01
Award Amount: $99,850.00
 

Abstract:

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project aims to investigate the feasibility of developing new compounds capable of utilizing common marker gene expression in transformed cells to control the growth and character of cells in living tissue. If successful, the proposed research will provide breakthroughs needed to advance the promising medical uses of recombinant genes. In Phase I of this project, Marker Gene Technologies proposes to establish the feasibility of the technology by preparing new D-luciferin conjugates of common growth regulators, drugs and enzyme inhibitors, for administration to animal cells or bacteria that contain either the firefly luciferase gene (luc) as a gene fusion marker. These new conjugates will provide innovative methods of utilizing this reporter gene system in transformed cells to affect drug delivery and control selected biological properties. In Phase I, the new conjugates will be assayed in vitro and in vivo for their ability to cause specific and localized inhibition or improvement of cell growth and to deliver activated drugs in a cell- or tissue-specific manner, In Phase II, the conjugates will be further tested in a variety of significant medical applications.

Principal Investigator:

John J. Naleway
5413423760
JNALEWAY@OREGON.UOREGON.EDU

Business Contact:

Alisa Naleway
5033441624
ALISANALEWAY@HOTMAIL.COM
Small Business Information at Submission:

MARKER GENE TECHNOLOGIES
MARKER GENE TECHNOLOGIES 3247 LINCOLN ST EUGENE, OR 97405

EIN/Tax ID: 931228900
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No