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On Orbit Immuno-Based, Label-Free, White Blood Cell Counting System with…

Award Information

National Aeronautics and Space Administration
Award ID:
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Aurora Flight Sciences Corporation
4 Cambridge Center 11th Floor Cambridge, MA 02142-1494
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2010
Title: On Orbit Immuno-Based, Label-Free, White Blood Cell Counting System with MicroElectroMechanical Sensor (MEMS) Technology (OILWBCS-MEMS)
Agency: NASA
Contract: NNX10CB07C
Award Amount: $599,988.00


Aurora Flight Sciences Corporation and partner, Draper Laboratory, propose to develop an on-orbit immuno-based label-free white blood cell counting system using MEMS technology (OILWBCS-MEMS) for human spaceflight experimental and medical monitoring practices. Our proposed system is designed to meet NASA's requirements for a microgravity compatible, miniaturized, light weight peripheral blood cell counting instrument capable of on-orbit cell counting, without high energy lasers, requiring minimal sample volume or exogenous (sheath) fluid, and generating minimal bio-hazardous waste: SBIR topic X14.02 "On Orbit Cell Counting and Analysis Capability". The proposed detection technology leverages changes in optical transmission through a surface due to molecular binding (e.g., antibody-antigen binding). Antibodies specific to the white blood cell surface protein markers (antigens) are pre-coated on the sensor surface to recognize specific white blood cell types with inherently high specificity and sensitivity. In Phase I we developed surface chemistry and demonstrated surface chemistry sensitivity and specificity for total white blood cells and two lymphocyte subtypes (B-cells, CD4+ T-cells). During phase II we will develop a functional prototype of the OILWBCS-MEMS device to demonstrate that end-to-end operations from sample-in to signal-out produces clinically relevant results. The OILWBCS-MEMS design will include single-use replaceable cartridges for fluid loop and sensor components.

Principal Investigator:

Dr. Jessica Edmonds
Principal Investigator

Business Contact:

Scott Hart
Financial Analyst
Small Business Information at Submission:

Aurora Flight Sciences Corporation
9950 Wakeman Drive Manassas, VA 20110

EIN/Tax ID: 541502935
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No