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Company Information:

Name: MARTEK BIOSCIENCE CORPORATION
Address: 6480 DOBBIN RD
COLUMBIA, MD 21045
Located in HUBZone: No
Woman-Owned: No
Minority-Owned: No
URL: N/A
Phone: (410) 740-0081

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,599,973.00 30
SBIR Phase II $5,929,658.00 14

Award List:

THIOBACILLUS FERROOXIDANS FOR ENHANCED METAL LEACHING CAPABILITIES.

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: NSF
Principal Investigator: John c cox phd , SCIENTIST
Award Amount: $36,000.00
Abstract:
Thiobacillus ferrooxidans catalyzes iron (ii) oxidation and heavy metal leaching from low grade ores by a complex process. biological leaching is a composite of direct oxidation of metals by the organism and the oxidizing activity of fe3+ produced by biological oxidation of feso4. the blue copper… More

BIOLOGICAL PRODUCTION OF NOVEL DEUTERATED LUBRICANTS

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: NSF
Principal Investigator: Dr David J Kyle , Research Director
Award Amount: $40,000.00

LUBRICANTS AND POLYMERS

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Dr david j kyle
Award Amount: $49,931.00
Abstract:
Perdeuterated synthetic oils have recently been shown to exhibit exceptional characteristics in terms of stability to high temperatures and oxidizing environments. in spite of these advantages, the high costs of chemical perdeuteration have restricted the use of these compounds to circumstances in… More

GENE (S) CONFERRING TOLERANCE TO THE HERBICIDE DIURON WILL BE ISOLATED BY COMPLEMENTATION OF THE HERBICIDE SENSITIVE WILD TYPE PHENOTYPE OF CHLAMYDOMONAS REINHARDII.

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: USDA
Principal Investigator:
Award Amount: $48,795.00
Abstract:
Gene (s) conferring tolerance to the herbicide diuron will be isolated by complementation of the herbicide sensitive wild type phenotype of chlamydomonas reinhardii. dna will be isolated fromt he well characterized, diuron-tolerant strains of chlamydomonas (dr8,dr9,and dr10) and represent ative… More

BIODEUTERATION: A BIOTECHNOLOGICAL APPROACH TO THE PRODUCTION OF PERDEUTERATED LUBRICANTS AND POLYMERS

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr. David J. Kyle , Principal Investigator
Award Amount: $49,931.00

BIODEUTERATION: A BIOTECHNOLOGICAL APPROACH TO THE PRODUCTION OF PERDEUTERATED LUBRICANTS AND POLYMERS

Award Year / Program / Phase: 1987 / SBIR / Phase II
Agency: DOE
Principal Investigator: Dr. David J. Kyle , Principal Investigator
Award Amount: $482,898.00
Abstract:
Perdeuterated synthetic oils have recently been shown to exhibit exceptional characteristics in terms of stability tohigh temperatures and oxidizing environments. in spite of these advantages, the high costs of chemical perdeuteration have restricted the use of these compounds to circumstances in… More

GENETIC AND BIOCHEMICAL STUDIES WITH THIOBACILLUS FERROOXIDANS FOR ENHANCED METAL RECOVERY FROM LEACH PILES AND COAL WASTE.

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: NSF
Principal Investigator:
Award Amount: $40,000.00
Abstract:
Metals recovery from leach piles and coal wastes (fly ash and bottom ash from burning) can be a valuble source of strategically important metals. in addition, runoff and leachates from coal wastes contain potentially toxic heavy metals such as arsenic, selenium, cadmium, and mercury that can have… More

OMEGA-3 POLYUNSATURATED FATTY ACIDS FROM ALGAE

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: David J Kyle Phd
Award Amount: $50,000.00

BIOLOGICAL PRODUCTION OF NOVEL DEUTERATED LUBRICANTS

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: NSF
Principal Investigator: Dr David J Kyle , Research Director
Award Amount: $202,000.00
Abstract:
The production of deuterium-substituted oils by autotrophic growth of certain algal species in deuterium oxide will be investigated. due to the increased carbon- deuterium bond strength, deuterated lubricant oils and greases exhibit superior capabilities under temperature and pressure extremes… More

OMEGA-3 POLYUNSATURATED FATTY ACIDS FROM ALGAE

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: HHS
Principal Investigator: David J Kyle Phd
Award Amount: $473,000.00
Abstract:
Recent investigations indicate a significant correlation between dietary supplements of polyunsaturated fatty acids (pufa), especially omega-3 pufas, and reduced incidence of coronary heart disease. clinical interests have focused on potential usage of omega-3 pufas, in the treatment of… More

ISOLATION AND CHARACTERIZATION OF PIGMENTS FROM ALGAE FOR USE AS NATURAL COLORANTS.

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: NSF
Principal Investigator: John c cox
Award Amount: $47,000.00
Abstract:
Most synthetic colors are coal tar derivatives and have been targetted as potential causative agents of hyperactivity and learning disabilities in children, cancer,embryotoxicity and allergenicity. alternatively, natural colors (e.g., carotenoids) do not exhibit these negative attributes, and may… More

INEXPENSIVE PRODUCTION OF UNIVERSALLY LABELLED CARBON-13 BIOMOLECULES BY ALGAE

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $46,000.00

ENZYMES OF OMEGA-3 FATTY ACID BIOSYNTHESIS

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

ENZYMES OF OMEGA-3 FATTY ACID BIOSYNTHESIS

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator: Scott E. Bingham
Award Amount: $49,920.00

ENZYMES OF OMEGA-3 FATTY ACID BIOSYNTHESIS

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $307,257.00
Abstract:
Recent clinical investigations have indicated that dietary supplements of eicosapentaenoic acid (epa) can reduce serum triglyceride and cholesterol levels. furthermore, initial studies have reported a selective killing of certain human cancer cells by treatment of this omega-3 polyunsaturated fatty… More

TRANSFORMATION STUDIES WITH THIOBACILLUS FERROOXIDANS AS A PREREQUISITE FOR STRAIN IMPROVEMENT FOR STRATEGIC METALS RECOVERY

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: NSF
Principal Investigator: Jon C Cox , Principal Investigator
Award Amount: $43,876.00
Abstract:
Estimates that suggest that metallic ore deposits are being depleted though the requirement for metals (especially strategically important ones) are increasing. toxic-metal rich waste occurs in several industrial processes, and organisms such as thiobacillus ferrooxidans could be used to detoxify… More

PRODUCTION OF STABLE ISOTOPICALLY-LABELLED L-LACTATE

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $43,437.00

13C-LABELED TRIOLEIN FOR DIAGNOSTIC BREATH TESTS

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $49,932.00

DOCOSAHEXAENOIC ACID FROM MICROALGAE

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $49,904.00

ENZYMES OF OMEGA-3 FATTY ACID BIOSYNTHESIS

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: HHS
Principal Investigator: David J. Kyle
Award Amount: $256,689.00

INEXPENSIVE PRODUCTION OF UNIVERSALLY LABELLED CARBON-13 BIOMOLECULES BY ALGAE

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $277,130.00
Abstract:
Stable isotopes are widely used in diagnosis of diseases anddisorders in gastro-enterology. they also find application as tracers for metabolic studies. they are non-invasive and non-toxic. algae fix co(2) and can therefore incorporate (13)co(2) into biomolecules that can be used as isotopic… More

BIOPRODUCTION OF SULFOQUINOVOSYLDIGLYCERIDE BY MICROALGAE

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: David J Kyle
Award Amount: $47,000.00
Abstract:
Researchers at the national cancer institute (nci) have recently identified a sulfolipid (sulfoquinovosyldiglyceride) that exhibits anti-aids activity in cultured human cell lines. this sulfolipid was extracted from marine blue-green microalgae, but the sqd productivity of the two key species was… More

PRODUCTION OF STABLE ISOTOPICALLY LABELED GLYCEROL

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Paul Behrens
Award Amount: $49,475.00

13C-LABELED TRIOLEIN FOR DIAGNOSTIC BREATH TESTS

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $462,190.00
Abstract:
The (14)c-triolein breath test is a poplar alternative to the classical 72-hour fecal fat collection for measuring fat malabsorption because of its simplicity and the rapidity with which a diagnosis can be made. however, because of the concern for the long-term effects of low-level radiation… More

DOCOSAHEXAENOIC ACID FROM MICROALGAE

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $470,166.00
Abstract:
Docosahexaenoic acid (dha) is the most abundant long-chain polyunsaturated fatty acid in the grey matter of the brain. humans can convert dietary linolenic acid into dha, but this process is slow. consequently, at the time of the mostrapid brain development in the first few months of life, there is… More

PRODUCTION OF STABLE ISOTOPICALLY-LABELLED L-LACTATE

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $498,987.00
Abstract:
Deuterated or 13-carbon-labeled l-lactate is widely used in medical diagnosis and clinical research. the stable, isotopically labeled lactate is nontoxic, and no ethical or disposal problems deter its use in human subjects. by virtue of their ability to grow in d2o instead of h2o and touse (13)co2… More

PRODUCTION OF STABLE ISOTOPICALLY LABELED GLYCEROL

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: HHS
Principal Investigator: Paul Behrens
Award Amount: $436,588.00
Abstract:
The presence of enriched stable isotope contents in proteins, coupled with sophisticated two- and three-dimensional nuclear magnetic resonance techniques, enables a rapid and easy determination of amino acid sequence and protein structure. glycerol is often used as the sole carbon source for the… More

EICOSAPENTAENOIC ACID FROM HETEROTROPHIC MICROALGAE

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kyle, David J , Principal Investigator
Award Amount: $50,000.00
Abstract:
The overall goal of this project is to manufacture an oil derived from algae which is enriched in omega-3 polyunsaturated fatty acids. preliminary data have shown there is a diatom which produces a non-membrane associated triglyceride with a high content of epa but low contents of other… More

PRODUCING NATURAL BETA-CAROTENE FOR CHEMOTHERAPEUTIC USE

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kyle, David J , Principal Investigator
Award Amount: $50,000.00
Abstract:
Beta-carotene (provitamin a) has recently been shown to be an effective chemotherapeutic agent in the treatment and prevention of cancer. moreover, carotenes produced biosynthetically (containing 9-cis isomers) appear to be a more effective antitumor agents than those presently manufactured… More

STABLE ISOTOPICALLY LABELED RIBONUCLEOSIDE PRODUCTION

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Fc Thomas Allnut
Award Amount: $49,989.00

STABLE ISOTOPE LABELED PROTEIN FOR METABOLIC STUDIES

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: F C Thomas Allnutt
Award Amount: $49,176.00
Abstract:
Uniformly labeled proteins and amino acids promise to become very powerful tools for the study of protein metabolism in humans and other animals. this project will test the feasibility of economically producing uniformly labeled ribulose-1, 5-bisphosphate carboxylase/oxygenase, a vegetable protein,… More

A NEW SOURCE OF ARACHIDONIC ACID FOR INFANT FORMULA

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: David J Kyle
Award Amount: $49,920.00
Abstract:
During the first year of life, a well fed infant may triple its body mass. consequently, this is a period of peak demand for arachidonic acid (ara), a long chain polyunsaturated fatty acid (pufa) that is a major structural lipid in peripheral and organ tissues. this is naturally provided to the… More

SMALL PHYCOBILIPROTEINS FOR USE AS FLUORESCENT MARKERS

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: F C Allnutt
Award Amount: $48,319.00

STABLE ISOTOPICALLY LABELED RIBONUCLEOSIDE PRODUCTION

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: HHS
Principal Investigator: Fc Thomas Allnut
Award Amount: $500,000.00
Abstract:
Stable isotope enrichment in synthetically prepared oligonucleotides coupled with multi-dimensional nmr techniques will greatly enhance the sensitivity and resolution of this technique when applied to the study of rna. this enhancement of the nmr technique will enable a rapid and easy determination… More

SMALL PHYCOBILIPROTEINS FOR USE AS FLUORESCENT MARKERS

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: HHS
Principal Investigator: F C Allnutt
Award Amount: $519,842.00
Abstract:
Phycobiliproteins are currently being used as fluorescent markers in many aspects of immunodetection of antigens (e.g. flow cytometry). the currently available phycobiliproteins all exceed 100 kda molecular weight. a whole class of phycobiliproteins have not been used for this purpose, those that… More

Noninvasive Test for Pancreatic Function

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: David J. Kyle
Award Amount: $49,951.00
Abstract:
Noninvasive diagnostic tests of the function of internal organs are of great value to clinical diagnoses. With respect to pancreatic function, the 72-hr fecal fat test is the "gold standard". However, due to the problematic compliance when used as an outpatient test, the high cost when… More

13C-Galactose Breath Test to Measure Liver Function

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Paul W. Behrens
Award Amount: $47,800.00

13C-Galactose Breath Test to Measure Liver Function

Award Year / Program / Phase: 1995 / SBIR / Phase II
Agency: HHS
Principal Investigator: Paul W. Behrens
Award Amount: $742,911.00
Abstract:
The liver performs diverse and important metabolic functions in human metabolism, and therefore liver dysfunction can lead to serious health consequences. As a result, many different tests are used to assess liver function. Although these tests provide information concerning the metabolic state of… More

Specific Action of Docosahexaenoic Acid on Hypertension

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: David Kyle
Award Amount: $69,111.00
Abstract:
Recent studies have suggested that fish oils may have an antihypertensive effect, and several studidone to test these effects using the spontaneously hypertensive rat (SHR) model. These studies haveresults, and there has been no consensus about the mode of action of fish oil on hypertension. One… More

Inexpensive Stable Isotopically Labeled Protein

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: F Allnutt
Award Amount: $100,000.00
Abstract:
This research will develop inexpensive production methods for uniformly stable isotopically labeledproteins by utilizing microalgal systems for protein expression. These methods would take advantageassociated with the microalgal use of simple carbon and nitrogen sources versus heterotrophic… More

SBIR PHASE I: Diatom Transformation for Product Enhancement

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: NSF
Principal Investigator: F. C. Thomas Allnutt
Award Amount: $75,000.00

Diatom Transformation for Product Enhancement

Award Year / Program / Phase: 1998 / SBIR / Phase II
Agency: NSF
Principal Investigator: F. C. Thomas Allnutt
Award Amount: $300,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: USDA
Principal Investigator: Paul W. Behrens
Award Amount: $69,506.00

HOMOGENEOUS ASSAY FOR SPECIFIC DNA/RNA SEQUENCE BY FRET

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Colleen M. Toole
Award Amount: $100,000.00
Abstract:
APPLICANT?S DESCRIPTION: The proposed research project will develop a homogeneous assay platform for nucleic acid diagnostics that brings improvements based on ease of use (a true "mix and read" format) and quantification, while approaching the sensitivity possible with the much more cumbersome PCR… More