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BIOPRODUCTION OF SULFOQUINOVOSYLDIGLYCERIDE BY MICROALGAE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13743
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13743
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MARTEK BIOSCIENCE CORPORATION
6480 DOBBIN RD COLUMBIA, MD 21045
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: BIOPRODUCTION OF SULFOQUINOVOSYLDIGLYCERIDE BY MICROALGAE
Agency: HHS
Contract: N/A
Award Amount: $47,000.00
 

Abstract:

RESEARCHERS AT THE NATIONAL CANCER INSTITUTE (NCI) HAVE RECENTLY IDENTIFIED A SULFOLIPID (SULFOQUINOVOSYLDIGLYCERIDE) THAT EXHIBITS ANTI-AIDS ACTIVITY IN CULTURED HUMAN CELL LINES. THIS SULFOLIPID WAS EXTRACTED FROM MARINE BLUE-GREEN MICROALGAE, BUT THE SQD PRODUCTIVITY OF THE TWO KEY SPECIES WAS ONLY 0.1-0.3 MG/LITER/DAY. MARTEK CORPORATION HAS RECENTLY IDENTIFIED A MICROALGAL ISOLATE IN ITS CULTURE COLLECTION (MK8908) THAT IS A NATURAL OVERPRODUCER OF SQD AND HAS OPTIMIZED ITS GROWTH SUCH THAT THE SQD PRODUCTIVITY IS ABOUT 200-250 MG/LITER/DAY (1,000-FOLD HIGHER THAN THE BLUE-GREEN MICROALGAE). DURING PHASE I, IT IS PLANNED TO SCREEN OVER 250 MUTANT ISOLATES OF THIS ORGANISM FOR SQD PRODUCTIVITY, TO MANIPULATE THE GROWTH CONDITIONS OF A SINGLE STRAIN AND DETERMINE WHICH PARAMETERS INFLUENCE SQD PRODUCTION, AND TO PRODUCE 20 GRAMS OF PURIFIED SDQ FOR NCI RESEARCHERS USING THE OPTIMIZED CONDITIONS. IT IS HOPED THAT WITH THE FURTHERUNDERSTANDING OF THE BIOCHEMISTRY AND METABOLISM OF THIS NEWLY IDENTIFIED ANTI-AIDS COMPOUND, THIS WILL BE ANOTHER STEP FORWARD IN ELIMINATING THIS FATAL DISEASE.

Principal Investigator:

David J Kyle
3017400081

Business Contact:

Small Business Information at Submission:

Martek Corp
6480 Dobbin Rd Columbia, MD 21045

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No