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IMPROVED MICROPOROUS MEMBRANES FOR MAMMALIAN CELL CULTURE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13893
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
13893
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MATTEK CORPORATION
200 HOMER AVE ASHLAND, MA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1991
Title: IMPROVED MICROPOROUS MEMBRANES FOR MAMMALIAN CELL CULTURE
Agency: HHS
Contract: N/A
Award Amount: $484,594.00
 

Abstract:

MICROPOROUS MEMBRANES OFFER RESEARCHERS MANY EXPERIMENTAL ADVANTAGES OVER OTHER CELL CULTURE METHODS. IN ADDITION, CELLS CULTURED ON SUCH MEMBRANES EXHIBIT ENHANCED DIFFERENTIATION AND MANY OTHER PROPERTIES THAT CLOSELY RESEMBLE THOSE OBSERVED IN VIVO. HOWEVER, CURRENTLY THE USE OF SUCH MEMBRANES IS LIMITED TO NONANCHORAGE-DEPENDENT CELLS OR REQUIRES THAT THE MEMBRANES BE COATED WITH AN EXTRACELLULAR MATRIX (ECM), SUCH AS COLLAGEN OR POLY-LYSINE, IN ORDER TO ALLOW ANCHORAGE-DEPENDENT CELL ATTACHMENT AND GROWTH. THIS REQUIREMENT OF AN ECM NEGATES MANY OF THE POSITIVE ASPECTS OFFERED BY USING THESE MEMBRANES. THIS RESEARCH WILL INVESTIGATE THE USE OF LOW-TEMPERATURE PLASMA SURFACE MODIFICATION TO DEVELOP MICROPOROUS MEMBRANESTHAT SUPPORT ANCHORAGE-DEPENDENT, MAMMALIAN CELL CULTURE WITHOUT THE NEED FOR AN ECM COATING.

Principal Investigator:

Mitchell Klausner
5088816771

Business Contact:

Small Business Information at Submission:

Mattek Corp.
200 Homer Ave Ashland, MA 01721

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No