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CELL CULTURE SURFACES FOR BONE RESEARCH

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16347
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
16347
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MATTEK CORPORATION
200 HOMER AVE ASHLAND, MA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1991
Title: CELL CULTURE SURFACES FOR BONE RESEARCH
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

SURFACES FOR CELL CULTURE ARE USED IN MANY AREAS OF BONE RESEARCH. THE STUDY OF OSTEOBLAST CELL CULTURE IS CURRENTLY USED TO EXAMINE THE MOLECULAR MECHANISMS LEADING TO BONE GROWTH, MORPHOLOGY AND MINERALIZATION. UNDERSTANDING OF THESE MOLECULAR MECHANISMS GIVES INSIGHT INTO THE ORIGINS AND TREATMENT OF VARIOUS BONE DISORDERS INCLUDING GROWTH DISORDERS IN CHILDREN AND OSTEOPOROSIS IN POST MENOPAUSAL WOMEN. RECENTLY CONSIDERABLE INTEREST HAS ARISEN IN THE EFFECTS OF MECHANICAL STRAIN ON THE GROWTH OF THESE CELLS. WHILE SOME FLEXIBLE MATERIALS FOR CELL CULTURE UNDER CYCLICALLY INDUCED STRAIN HAVE BEEN PROPOSED, THE SURFACE CHEMISTRY OF MOST FLEXIBLE MATERIALS IS NOT WELL SUITED TO CELL CULTURE AND REQUIRES COATING OR OTHER SURFACE MODIFICATION PRIOR TO USE. THIS RESEARCH WILL FOCUS ON THE PLASMA SURFACE MODIFICATION OF THREE MATERIALS OF CURRENT INTEREST IN THE AREA OF OSTEOBLAST CELL CULTURE AND DETERMINE THE EFFECTS OF SURFACE TREATMENT ON THE COURSE OSTEOBLAST CELL CULTURE AND SUBSEQUENT MINERALIZATION.

Principal Investigator:

Klausner, Mitchell
Principal Investigator
5088816771

Business Contact:

1 r43 ar40797-01
Small Business Information at Submission:

Mattek Corpon
200 Homer Ave- Nue Ashland, MA 01721

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No