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Cultured Corneal Epithelium-Draize Test Replacement

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22214
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
22214
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MATTEK CORPORATION
200 HOMER AVE ASHLAND, MA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1995
Title: Cultured Corneal Epithelium-Draize Test Replacement
Agency: HHS
Contract: N/A
Award Amount: $604,335.00
 

Abstract:

One of the most controversial toxicology tests currently performed is the Draize rabbit eye irritancy test. In addition to the moral outcry against the procedure, the Draize test has been criticized due to the high degree of inter- and intra-laboratory variability, its lack of objectivity, and the extra sensitivity of the rabbit eye in comparison to the human eye. Nonetheless, the Draize test has become the standard ocular toxicological testing method since it was developed nearly 50 years ago. The purpose is to develop an alternative to the Draize test which is a reliable predictor of ocular toxicity. The alternative is a cell culture based corneal analog whose cellular and tissue-like behavior can be quantified in a well defined, reproducible manner as a function of exposure to a potential toxicant or irritant. Such a system would remove the subjectivity of the Draize method, increase reproducibility, and avoid the moral problems of inhumane treatment of animals.

Principal Investigator:

Mitchell Klausner
5088816771

Business Contact:

Small Business Information at Submission:

Mattek Corp.
200 Homer Avenue Ashland, MA 01721

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No