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In Vitro Tissue Model of Psoriasis

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
80036
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
AR052982
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MATTEK CORPORATION
200 HOMER AVE ASHLAND, MA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2006
Title: In Vitro Tissue Model of Psoriasis
Agency: HHS
Contract: 1R43AR052982-01A1
Award Amount: $210,982.00
 

Abstract:

DESCRIPTION (provided by applicant): Psoriasis is a chronic inflammatory and proliferative skin disease that affects 2-3% of the population in Western countries and an estimated 80 million people worldwide. The disease causes disfiguration in 10- 30% of cases and arthiritis in 10-15% of patients. Although attempts are made to model aspects of psoriasis in animals, none of the models reproduce the complex psoriatic phenotypes that are observed in humans. The availability of an in vitro psoriasis model to screen candidate drugs and to gain a better understanding of the biological mechanisms involved in psoriatic disease would be valuable. During Phase I, a human cell based in vitro psoriatic tissue equivalent (PTE) will be developed. Keratinocytes, fibroblasts, dendritic cells, and T-cells will be harvested from psoriatic patient samples and used to reconstruct highly differentiated skin tissues. The histology, ultrastructure, cytokine release, and protein expression of the PTE will be characterized with emphasis on characteristics distinctive of psoriatic tissue. Comparisons to involved and uninvolved skin samples from psoriatic patients will be made. Finally, an overall assessment of the PTE feasibility for commercial purposes will be made. We anticipate that the PTE will have advantages over current animal models due to cost, its human origin, ability to be adapted to high throughput screening formats, and the possibility of modeling different psoriatic phenotypes.

Principal Investigator:

Seyoum Ayehunie
5088816771
SAYEHUNIE@MATTEK.COM

Business Contact:

John Sheasgreen
5088816771
JSHEASGREEN@MATTEK.COM
Small Business Information at Submission:

MATTEK CORPORATION
MATTEK CORPORATION 200 HOMER AVE ASHLAND, MA 01721

EIN/Tax ID: 042877744
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No