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Implantable Glucose Sensor with Prolonged Accuracy

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
80600
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
DK074243
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Michigan Critical Care Consultants, Inc.
3550 West Liberty Suite 3 Ann Arbor, MI -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2006
Title: Implantable Glucose Sensor with Prolonged Accuracy
Agency: HHS
Contract: 1R43DK074243-01
Award Amount: $145,049.00
 

Abstract:

DESCRIPTION (provided by applicant): The goal in this study is to fabricate an intravascular glucose sensor that functions accurately for 3 days in vivo. To do this, we will develop an outer membrane that facilitates the conversion of endogenous S- nitrosothiols to nitric oxide locally at the membrane/blood interface. Since nitric oxide is released by the endothelial cells and is responsible for maintaining vascular tone and platelet inactivation, this is a natural approach that mimics the functions of the endothelium. This study involves the design of a biocompatible glucose-selective membrane, fabrication of a functional glucose sensor, and bench and animal testing to assess biocompatibility and function of the sensor. Continuous monitoring of blood glucose levels has been an elusive goal, but would greatly improve the care for critically ill patients in managing insulin therapy.

Principal Investigator:

Melissa M. Reynolds
7349959089
REYNOLDS@MC3CORP.COM

Business Contact:

Sean Chambers
7349959089
schambers@mc3corp.com
Small Business Information at Submission:

MC3, INC.
MC3, INC. 3550 W LIBERTY RD ANN ARBOR, MI 48103

EIN/Tax ID: 382667222
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No