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BIOLOGICALLY STABLE HEPARIN DERIVATIVES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7336
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7336
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Mccann Associates Inc
3139 South Wayne Road Wayne, MI 48184
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: BIOLOGICALLY STABLE HEPARIN DERIVATIVES
Agency: HHS
Contract: N/A
Award Amount: $42,000.00
 

Abstract:

A SERIES OF COVALENT HEPARIN-PROTEIN COMPLEXES WITH PROLONGED IN VIVO HALF-LIVES OF THE HEPARIN MOIETY AND HIGH ANTICOAGULANT ACTIVITY WILL BE DEVELOPED. A SERIES OF PROTEINS COVERING A BROAD RANGE OF MOLECULAR WEIGHTS AND ISOELECTRIC POINTS WILL BE CHOSEN FOR THESE CONJUGATES. VARIOUS CONJUGATION TECHNIQUES WILL BE INVESTIGATED TO DETERMINE THE METHOD THAT WILL RETAIN THE BEST ANTICOAGULANT ACTIVITY FOR THE HEPARIN. THE RELATIVE ABILITY OF THE COVALENT PROTEIN-HEPARIN COMPLEXES TO CATALYTICALLY ACCELERATE THE INHIBITION OF THROMBIN AND FACTOR X WILL BE MEASURED BY STOPPED-FLOW FLUORIMETRY. PROLONGATION OF ACTIVATED PARTIAL THROMBOPLASTIN TIME WILL BE USED TO EVALUATE POTENTIAL IN VIVO ANTICOAGULANT ACTIVITY. ULTIMATELY, BUT NOT AS PART OF THE PHASE I STUDIES, HALF-LIVES AND EFFICACY WILL BE DETERMINED IN CONTROLLED CLINICAL STUDIES.

Principal Investigator:

Daisy s mccann phd
3137210300

Business Contact:

Small Business Information at Submission:

Mccann Associates Inc
3139 South Wayne Road Wayne, MI 48148

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No