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USE OF RECOMBINANT MYCOBACTERIAL VACCINES FOR MALARIA

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13635
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13635
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MEDIMMUNE, INC.
35 WEST WATKINS MILL RD Gaithersburg, MD 20878
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: USE OF RECOMBINANT MYCOBACTERIAL VACCINES FOR MALARIA
Agency: HHS
Contract: N/A
Award Amount: $49,000.00
 

Abstract:

MALARIA, ONE OF THE MOST WIDESPREAD INFECTIOUS DISEASES OF HUMANS, THREATENS ALMOST HALF THE WORLD'S POPULATION. CURRENTLY, THERE ARE AN ESTIMATED 350+ MILLION ACUTE CASES WORLDWIDE EACH YEAR, AND APPROXIMATELY 1 TO 2 MILLION INFANTS AND YOUNG CHILDREN DIE IN AFRICA ALONE BECAUSE OF THE DISEASE. TRADITIONAL METHODS OF CONTROLLING MALARIA WITH INSECTICIDES AND DRUGS HAVE BEEN INADEQUATE. THUS, INCREASED ATTENTION HAS FOCUSED ON DEVELOPING A SAFE AND EFFECTIVE VACCINE AGAINST THE PARASITE. THE OBJECTIVE OF PHASE I IS TO ASSESS THE PROTECTIVE EFFICACY OF IMMUNIZATION WITH RECOMBINANT MYCOBACTERIAL (E.G., BCG) VACCINES CONTAINING THE GENE FROM THE MAJOR SURFACE PROTEIN OF MALARIA SPOROZOITES WITH THE GOAL OF INDUCING PROTECTIVE CELL-MEDIATED IMMUNITY. A PLASMODIUM BERGHEI RODENT MALARIA MODEL WILL BE UTILIZED AS NO RELIABLE ANIMAL MODEL IS CURRENTLY AVAILABLE FOR THE HUMAN MALARIA PARASITES. P. FALCIPARUM AND P. VIVAX. DATA FROM THIS STUDY WILL BE USED TO ESTABLISH PRINCIPLES THAT CAN BE APPLIED TO THE DEVELOPMENT OF NOVEL VACCINE CANDIDATES FOR THE HUMAN MALARIA PARASITES. THIS APPROACH IS OF SPECIAL INTEREST BECAUSE BCG IS CURRENTLY USED FOR VACCINATION IN THE WHO/EXPANDED PROGRAM FOR IMMUNIZATION IN DEVELOPING COUNTRIES WHERE MALARIA IS ENDEMIC.

Principal Investigator:

Vidal F De La Cruz
3015902621

Business Contact:

Small Business Information at Submission:

Medimmune Inc
19 Firstfield Rd Gaithersburg, MD 20878

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No