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Company Information:

Company Name: Megabase Research Products
City: Lincoln
State: NE
Zip+4: 68504
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: (402) 467-6499

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $604,664.00 8
SBIR Phase II $1,883,177.00 4

Award List:

Efficient Coding Strategies for DNA Sequencing

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Robert M. Nelson
Award Amount: $49,951.00
Abstract:
Enzymatic dideoxy sequencing can be streamlined using algebraic coding strategies from communications theory. Using coding methods similar to those applied to telecommunications and digital electronics, the speed and efficiency of DNA sequencing can be substantially improved. One DNA template can be… More

Commercial Scale Production of Cvi Endonucleases

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Robert M. Nelson
Award Amount: $49,790.00

Commercial Scale Production of Cvi Endonucleases

Award Year / Program / Phase: 1995 / SBIR / Phase II
Agency: HHS
Principal Investigator: Robert M. Nelson
Award Amount: $454,680.00
Abstract:
Chlorella virus (Cvi) restriction nucleases are a large, untapped source of gene mapping tools that have considerable commercial potential. Unlike bacterial restriction endonucleases, which recognize 4 to 8 base pair (bp) DNA target sequences, Cvi endonucleases define unique 2 to 4 bp cleavage sites… More

Novel 2 to 4 Base Pair Specific Enzymes for PCR Fingerprinting

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: USDA
Principal Investigator: Dr. Michael Nelson , Principal Investigator
Award Amount: $50,000.00

Novel 2 to 4 Base Pair Specific Enzymes for PCR Fingerprinting

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: USDA
Principal Investigator: Dr. Michael Nelson , Principal Investigator
Award Amount: $150,000.00
Abstract:
A large number of RFLP variants in plant and animal diseases can be detected using the polymerase chain reaction (PCR) followed by restriction endonuclease cleavage. However, the resolution of PCR fingerprinting techniques is limited by rather long (4 to 6 base pair) DNA sequence specificities of… More

RAPID SCREENING ASSAY FOR ANTIPROLIFERATIVE DRUGS

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Nelson, michael
Award Amount: $94,438.00

DNA METHYLTRANSFERASE GENOTYPING

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Lopez, osvaldo j
Award Amount: $76,738.00

DNA MTASE GENOTYPING OF ENTEROHEMORRHAGIC E COLI

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Padhye, Nisha V
Award Amount: $85,637.00

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency: HHS
Principal Investigator: Lopez osvaldo j
Award Amount: $535,136.00

RAPID PCR OF BACILLUS ANTHRACIS DNA

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Nisha V. Padhye
Award Amount: $98,330.00
Abstract:
DESCRIPTION (provided by applicant): Anthrax or Woolsorter's Disease is a zoonotic infection caused by Bacillus anthracis. During the peak of the 'anthrax letter scare of 2001', the US Army Medical Research Institute for Infectious Diseases was testing over 2000 samples per day. At the present time,… More

A PCR Jet for Rapid Detection of Special pathogens

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: HHS
Principal Investigator: Nisha V. Padhye
Award Amount: $743,361.00
Abstract:
DESCRIPTION (provided by applicant): Polymerase Chain Reaction (PCR) amplification of DNA is the most reliable method for the rapid detection of pathogens. The overall rate of the PCR process is determined by performance of both the thermocycler and the companion biochemistry used to enzymatically… More

SBIR Phase I: System Engineering of a Ranque-Hilsch Thermocycler

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: NSF
Principal Investigator: Scott Whitney, PI
Award Amount: $99,780.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project will develop an improved thermocycler for high speed PCR (Polymerase Chain Reaction) using a systems engineering approach, thereby improving the throughput of PCR by two orders of magnitude. The commercial application of this project… More