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METHADONE HYDROCHLORIDE IS WIDELU USED IN DRUG TREATMENT OF HEROIN ADDICTS AND…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
5331
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
5331
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Membrane Technology and Research, Inc.
39630 Eureka Drive Newark, CA 94560
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: METHADONE HYDROCHLORIDE IS WIDELU USED IN DRUG TREATMENT OF HEROIN ADDICTS AND EFFECTIVELY RELIEVES THE CRAVING FOR HEROIN.
Agency: HHS
Contract: N/A
Award Amount: $41,000.00
 

Abstract:

METHADONE HYDROCHLORIDE IS WIDELU USED IN DRUG TREATMENT OF HEROIN ADDICTS AND EFFECTIVELY RELIEVES THE CRAVING FOR HEROIN. HOWEVER, METHADONE IS ITSELF ADDICTIVE AND A DRUG OF ABUSE. AS A RESULT, DIVERSION OF METHADONE TO THE BLACK MARKET BY PATIENTS IS A SERIOUS PROBLEM, AND THE DRUG CANNOTUSUALLY BE GIVEN TO PATIENTS FOR SELF-MEDICATION. THERE IS REASON TO BELIEVE THAT METHADONE FREE BASE OR ACETYL METHADOL WOULD BE SUFFICIENTLY SKIN PERMEABLE TO ALLOW ADMINISTRATION AS A TRANSDERMAL PATCH, ESPECIALLY IF THE DRUG IS ADMINISTERED WITH A SKIN PERMEATION ENHANCER SUCH ASETHANOL OR PROPANOL. THIS RESEARCH PROPOSES TO DEVELOP SUCHA SYSTEM. BECAUSE METHADONE IN A TRANSDERMAL PATCH, COMPOUNDED WITH UNPALATABLE EXCIPIENT, WOULD NOT BE OPEN TO ABUSE, THIS APPROACH COULD ALLOW INNOVATIONS IN DRUG TREAT- MENT PROGRAMS. IN THE PROPOSED PHASE I PROGRAM, THE PERMEABILITY OF SKIN TO METHADONE FREE BASE AND ACETYL METHADOL WITH AND WITHOUT SKIN PERMEATION ENHANCERS WOULD BEDETERMINED. IF THESE RESULTS ARE SUFFICIENTLY ENCOURAGING, TRANSDERMAL DEVICES WOULD BE DEVELOPED IN A PHASE II PROGRAM, AND A COLLABORATIVE EFFORT WITH CLINICAL RESEARCH WOULD BE UNDERATKEN.

Principal Investigator:

J g wijmans
PRINCIPAL INVESTIGATOR
4153282228

Business Contact:

Small Business Information at Submission:

Membrane Technology & Rsch Inc
1030 Hamilton Court Menlo Park, CA 94025

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No