The Alcopatch is a new test for alcohol consumption which operates by transdermal dosimetry. It is worn as an adhesive wristband and collects ethanol excreted from the surface of the skin after any alcoholic beverages are consumed. The amount of ethanol measured in the Alcopatch varies with the… More

DESCRIPTION (provided by applicant): Background: Pulmonary tuberculosis (TB) is a growing public health problem, and detection is often costly and time-consuming. A breath test for volatile markers of Mycobacteria could provide a new test for the disease. An advanced new breath test routinely… More

DESCRIPTION: The problem: Oral malodor causes much despair, and treatment is frequently empirical and ineffective because the specific cause is not usually known. The basic problem that has retarded progress in the treatment of oral malodor is the lack of an objective method for evaluating the… More

DESCRIPTION (provided by applicant): Background: Pulmonary tuberculosis (TB) is a growing public health problem, but confirming the diagnosis in patients with suspected disease is often costly and time-consuming. Clinicians urgently need a screening test for active pulmonary tuberculosis that is… More

The objective of this proposal is to develop a non-invasive radiation bio-dosimeter by employing a mobile breathalyzer to measure biomarkers of oxidative stress in the breath. The rationale for this research is that gamma radiation causes tissue injury, resulting in increased electron leak of… More

The technical problem: In the event of a terrorist attack with a "dirty bomb", there would be an urgent need to distinguish between those who have and have not been exposed to radiation, in order to perform rapid triage. First responders and emergency health workers would require a biological… More

DESCRIPTION (provided by applicant): Background: An advanced breathalyzer system has been developed to collect and analyze volatile organic compounds (VOCs) in alveolar breath in picomolar concentrations (parts per trillion). This technology has made it p ossible to identify breath biomarkers of… More

DESCRIPTION (provided by applicant): The clinical problem: Approximately 3,500 people worldwide now undergo heart transplantation every year. Most heart transplant recipients are monitored for the development of organ rejection with a series of endomyocardial biopsies during the first twelve months… More