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USE OF A CCD CAMERA FOR LOW-COST CONFOCAL MICROSCOPY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16624
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
16624
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Meridian Instruments, Inc.
2310 SCIENCE PKY Okemos, MI 48864
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1992
Title: USE OF A CCD CAMERA FOR LOW-COST CONFOCAL MICROSCOPY
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

CONFOCAL MICROSCOPY IS ONE OF THE MOST SIGNIFICANT ADVANCES IN OPTICAL MICROSCOPY. ITS ABILITY TO VIRTUALLY ELIMINATE OUT-OF-FOCUS BLURRING PERMITS OPTICAL SECTIONING OF CELLS AND THICK TRANSPARENT SPECIMENS. THIS TECHNIQUE IS RAPIDLY BEING ADOPTED FOR THE THREE- DIMENSIONAL VISUALIZATION OF CELLULAR AND TISSUE ORGANIZATION. THE SPECIFIC AIMS OF THIS PROJECT ARE TO DETERMINE THE FEASIBILITY OF USING A SLIT SCANNING METHOD AND A CCD CAMERA TO PRODUCE OPTICAL SECTIONS OF FLUORESCENTLY STAINED BIOLOGICAL SPECIMENS. THE LONG TERM OBJECTIVE IS TO PROVIDE A RAPID, LOW-COST CONFOCAL IMAGING INSTRUMENT THAT CAN BE ATTACHED TO MOST CONVENTIONAL EPI-ILLUMINATION MICROSCOPES. TO THIS END, AN OPTICAL BREADBOARD WILL BE DEVELOPED THAT INCORPORATES A UNIQUE SCANNING DEVICE THAT SIMULTANEOUSLY SCANS A SPECIMEN AND A CCD CAMERA. THE SIMPLICITY OF THIS DESIGN IS EXPECTED TO REDUCE THE COST OF THE SYSTEM, AND THE USE OF A CCD CAMERA WILL PROVIDE THE FLEXIBILITY FOR CONFOCAL AND CONVENTIONAL VIDEO IMAGING. THE COMBINATION OF THESE INNOVATIONS WILL RESULT IN AN AFFORDABLE CONFOCAL MICROSCOPE THAT CAN BE USED FOR RESEARCH IN CELL BIOLOGY, NEUROBIOLOGY, CANCER, HISTOLOGY, PATHOLOGY AND MOLECULAR GENETICS. IN ADDITION, THE COST OF THIS INSTRUMENT SHOULD MAKE THIS TECHNOLOGY MORE AVAILABLE FOR CLINICAL AND INSTRUCTIONAL APPLICATIONS.

Principal Investigator:

Burrill, Peter H
Principal Investigator
5173497200

Business Contact:

1 r43 gm45640-01
Small Business Information at Submission:

Meridian Instruments, Inc.
2310 Science Parkway Okemos, MI 48864

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No