Validation of New Mass Spectrometric Blood Folate Assay

Award Information

Agency: Department of Health and Human Services	Branch: N/A	Award ID: 29403	Program Year/Program: 1996 / SBIR
Agency Tracking Number: 29403	Solicitation Year: N/A	Solicitation Topic Code: N/A	Solicitation Number: N/A

Small Business Information: Smd, Inc.
4200 E 9TH AVE, B-170 Denver, CO 80262
View profile »

Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No

Phase 2: Fiscal Year: 1996

Title: Validation of New Mass Spectrometric Blood Folate Assay

Agency: HHS

Contract: 1 R43 DK50519-01,

Award Amount: $538,447.00

Abstract:
We will develop methods to accurately measure molar amounts of total folates and individual folatefrom blood or tissues by gas chromatography/mass spectrometry (GCMS) using stable isotope labeled fostandards, which completely corrects for recovery. During Phase I, the intrinsic properties of a nebased assay for total folates will be tested by (a) assessing the feasibility of assaying large numbcomparing the reproducibility and precision of the new assay to a standard folate assay and (c) estaconditions for sample storage and transport. The total blood folate level from 50 individuals will binto 5 pools for precision studies. Within-run and between-run variability of the new method will bemethod. Optimal conditions of storage will be established. The project uses GC/MS technology and thebecome the "gold standard" in measurement of folates.

Principal Investigator:
Cheruppolil Santhosh-Kuma
30370

Business Contact:

Small Business Information at Submission:

Merrill Analytical Company
4200 E 9th Avenue, B-170 Denver, CO 80262

EIN/Tax ID:

DUNS: N/A

Number of Employees: N/A

Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No