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Validation of New Mass Spectrometric Blood Folate Assay

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29403
Program Year/Program:
1996 / SBIR
Agency Tracking Number:
29403
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Smd, Inc.
4200 E 9TH AVE, B-170 Denver, CO 80262
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1996
Title: Validation of New Mass Spectrometric Blood Folate Assay
Agency: HHS
Contract: 1 R43 DK50519-01,
Award Amount: $538,447.00
 

Abstract:

We will develop methods to accurately measure molar amounts of total folates and individual folatefrom blood or tissues by gas chromatography/mass spectrometry (GCMS) using stable isotope labeled fostandards, which completely corrects for recovery. During Phase I, the intrinsic properties of a nebased assay for total folates will be tested by (a) assessing the feasibility of assaying large numbcomparing the reproducibility and precision of the new assay to a standard folate assay and (c) estaconditions for sample storage and transport. The total blood folate level from 50 individuals will binto 5 pools for precision studies. Within-run and between-run variability of the new method will bemethod. Optimal conditions of storage will be established. The project uses GC/MS technology and thebecome the "gold standard" in measurement of folates.

Principal Investigator:

Cheruppolil Santhosh-Kuma
30370

Business Contact:

Small Business Information at Submission:

Merrill Analytical Company
4200 E 9th Avenue, B-170 Denver, CO 80262

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No