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SBIR Phase I: Radial-position Controlled Lanthanide Doped Nanocrystals as…

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
84744
Program Year/Program:
2007 / SBIR
Agency Tracking Number:
0711838
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MESOLIGHT, LLC
MESOLIGHT, LLC 4301 W Markham St #831 LITTLE ROCK, AR 72205
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2007
Title: SBIR Phase I: Radial-position Controlled Lanthanide Doped Nanocrystals as Time-resolved Fluorescence Imaging Agents
Agency: NSF
Contract: 0711838
Award Amount: $100,000.00
 

Abstract:

This Small Business Innovation Research (SBIR) Phase I project will develop highly bright and stable lanthanide doped semiconductor nanocrystals as Time-Resolved Fluorescence (TRF) imaging agents. Lanthanide chelates have exceptionally long fluorescence lifetimes, and thus are used as fluorescent probe in the time-resolved fluorescent imaging to minimize the autofluorescence which is typically characterized by a short fluorescence lifetime. However long-standing difficulties with lanthanide probes - e.g. the instability and poor compatibility with biomolecule, have limited their applications. The lanthanide doped semiconductor nanocrystals to be developed in this program would have the advantageous features of high brightness, high stability, easily surface modification to be compatible with biomolecules such as protein and DNA; and thus can be widely used in TRF imaging. The expansion of applications of bioimaging in the life and biomedical sciences is creating new market opportunity for imaging agents; of which, the market is huge and will grow from current $4.0 billion to above $5.0 billion before 2009. The commercialization of new type of lanthanide based TRF imaging agents will largely depend on the improvements in the luminescent efficiency and stability of the products. The broader impact of the technology from this project will be to enable more extensive use of time-resolved fluorescence imaging in the life and biomedical sciences.

Principal Investigator:

Yunjun L. Wang
DPhil
4797993368
yjwang@mesolight.com

Business Contact:

Yunjun L. Wang
DPhil
4797993368
yjwang@mesolight.com
Small Business Information at Submission:

Mesolight LLC
401 S Cedar Street UAMS/BioVentures Little Rock, AR 72205

EIN/Tax ID: 201419009
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No