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A 13C-XYLOSE BREATH TEST FOR BACTERIAL OVERGROWTH

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16545
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
16545
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
METABOLIC SOLUTIONS, INC.
METABOLIC SOLUTIONS, INC. 460 AMHERST ST NASHUA, NH 03063
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1994
Title: A 13C-XYLOSE BREATH TEST FOR BACTERIAL OVERGROWTH
Agency: HHS
Contract: N/A
Award Amount: $445,000.00
 

Abstract:

ANATOMIC AND PHYSIOLOGICAL DERANGEMENTS OF THE GASTROINTESTINAL TRACT CAN LEAD TO ABNORMAL OVERGROWTH OF THE SMALL INTESTINE. A QUANTITATIVE CULTURE OF AN ASPIRATE OF SMALL BOWEL FLUID IS USED TO DETECT BACTERIAL OVERGROWTH. THIS IS OFTEN NOT PERFORMED BECAUSE IT IS SO INCONVENIENT. THE NEED FOR A RELIABLE, NON-INVASIVE SCREENING TEST FOR BACTERIAL OVERGROWTH HAS LED TO THE DEVELOP- MENT OF BREATH TESTS USING RADIOACTIVE 14C SUBSTRATES. A ONE GRAM 14C-XYLOSE BREATH HAS BEEN EXTENSIVELY VALIDATED FOR THE SPECIFIC DIAGNOSIS OF BACTERIAL OVERGROWTH. HOWEVER, BECAUSE THE 14C-XYLOSE BREATH TEST USES A SMALL RADIOACTIVE DOSE OF XYLOSE, ITS USE IN CHILDREN AND PREGNANT WOMEN OR REPEATED USE, DEMANDS DEVELOPMENT OF A NON-RADIOACTIVE ALTERNATIVE TEST. WE WILL DEVELOP A SAFE, NON-RADIOACTIVE, ALTERNATIVE TO THE 14C-XYLOSE TEST USING INSTEAD THE STABLE ISOTOPE 13C. STABLE ISOTOPES SUCH AS 13C EMIT NO RADIATION AND ARE NATURALLY PRESENT IN OUR BODY. THE POTENTIAL COMMERCIAL APPLICATION OF THIS TECHNOLOGICAL INNOVATION IS THE DEVELOPMENT OF A SAFE AND ACCURATE XYLOSE BREATH TEST KIT FOR THE DETECTION OF SMALL BOWEL BACTERIAL OVERGROWTH. THE 13C-XYLOSE BREATH TEST KITS WILL BE EASY TO ADMINISTER IN ANY PHYSICIAN OFFICE AND WILL BE ACCURATE FOR DIAGNOSIS OF BACTERIAL OVERGROWTH.

Principal Investigator:

Wagner, David A
Principal Investigator
5086359914

Business Contact:

1 r43 dk44399-01
Small Business Information at Submission:

Metabolic Solutions, Inc.
33 Nagog Park Acton, MA 01720

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No