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VALIDATION OF CAFFEINE/METHACETIN 13C BREATH TESTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
19203
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
19203
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
METABOLIC SOLUTIONS, INC.
METABOLIC SOLUTIONS, INC. 460 AMHERST ST NASHUA, NH 03063
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1992
Title: VALIDATION OF CAFFEINE/METHACETIN 13C BREATH TESTS
Agency: HHS
Contract: N/A
Award Amount: $46,600.00
 

Abstract:

THIS STUDY WILL INVESTIGATE CAFFEINE AND METHACETIN BREATH TESTS IN NORMAL VOLUNTEERS AND VALIDATE THE USE OF THE TESTS FOR ASSESSING HEPATIC CYTOCHROME P450-IA2 ACTIVITY. THE EFFECT OF CHARCOAL BROILED BEEF AND CHANGES IN PROTEIN/CARBOHYDRATE RATIO ON THE HEPATIC METABOLISM OF THESE SUBSTRATES WILL BE EXAMINED. THE FUNDAMENTAL HYPOTEHSIS IS THAT THESE BREATH TESTS WILL ACCURATELY ESTIMATE HEPATIC MICROSOMAL ACTIVITY. THE LONG-TERM GOAL IS TO VALIDATE THESE TESTS FOR USE IN DRUG TRIALS. THE TESTS COULD THEN BE USED TO DETERMINE THE AMOUNT OF HEPATIC MICROSOMAL ACTIVITY OF SUBJECTS PARTICIPATING IN SUCH TRIALS. IT IS SUGGESTED THAT KNOWLEDGE OF THE EFFECT OF DIETARY AND ENVIRONMENTAL FACTORS ON DRUG METABOLISM WOULD LEAD TO MORE ACCURATE DETERMINATIONS ABOUT THERAPEUTIC DOSAGES FOR NEW DRUGS. STUDIES ARE PLANNED USING NORMAL HEALTHY SUBJECTS TO EXAMINE THE METABOLISM OF 13C-CAFFEINE AND 13C-METHACETIN DURING CONTROLLED DIETARY PERIODS. METABOLISM OF THE TEST COMPOUNDS WILL BE MONITORED BY ISOTOPE RATIO MASS SPECTROMETRY.

Principal Investigator:

David A Wagner
5086359914

Business Contact:

Small Business Information at Submission:

Metabolic Solutions Inc
33 Nagog Park Acton, MA 01720

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No