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A TECHNOLOGY WILL BE DEVELOPED FOR THE PRODUCTION OF MINIATURE BIOSENSORS THAT…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4888
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4888
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Michigan Research Corp
2901 Baxter Road Ann Arbor, MI 48109
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: A TECHNOLOGY WILL BE DEVELOPED FOR THE PRODUCTION OF MINIATURE BIOSENSORS THAT CAN BE USED FOR IN VIVO AND IN VITRO MONITORING OF LOW MOLECULAR WEIGHT ANALYTES (<1000) SUCH AS METABOLITES, DRUGS, HORMONES, AND TOXIC SUBSTANCES.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

A TECHNOLOGY WILL BE DEVELOPED FOR THE PRODUCTION OF MINIATURE BIOSENSORS THAT CAN BE USED FOR IN VIVO AND IN VITRO MONITORING OF LOW MOLECULAR WEIGHT ANALYTES (<1000) SUCH AS METABOLITES, DRUGS, HORMONES, AND TOXIC SUBSTANCES. THE TECHNOLOGY IS BASED ON FIBER OPTICS AND IMMUNOASSAY PRINCIPLES, THAT IS, A RECEPTOR IS SELECTED FOR A DRUG, AND THE QUENCHING OF A FLUORESCENTLY LABELED ANALOG OF THE DRUG IS USED TO MEASURE THE EXTENT OF BINDING BETWEEN RECEPTOR AND DRUG. WHILE IMMUNOASSAYS ARE DISCRETE TESTS, THE BIO- SENSOR TECHNOLOGY BEING DEVELOPED PROVIDES CONTINUOUS ONLINEMONITORING. THE ANTIBODY OR ITS EQUIVALENT AND A HIGH MW FLUORESCENT ANALOG ARE RETAINED IN A SELECTIVELY POROUS MICRO TEST TUBE, FORMED BY A HOLLOW DIALYSIS FIBER (-300 MICRONS DIAMETER). THE BIOSENSOR READILY RESPONDS TO EXTERNAL CONCENTRATION CHANGES OF ANALYTE DUE TO THE REVERSIBLE DISPLACEMENT OF THE FLUORESCENT ANALOG FROM THE RECEPTOR. FLUORESCENT INTENSITY IS MONITORED WITH A SINGLE OPTICAL FIBER INSERTED INTO THE HOLLOW DIALYSIS FIBER. THE USE OF FIBER OPTICS PROVIDES THE CAPABILITY FOR A WIDE VARIETY OF OPTICAL MEASUREMENTS, FOR EXAMPLE, COLORIMETRY, FLUORESCENCE, LIGHT SCATTERING, AND OPTICAL ROTATION, TO MEASURE THE EXTENT OF BINDING. EVENTUALLY, AS MINIATURE OPTIC ELECTRONIC DEVICES (SOLID STATE LASERS, PHOTO- DETECTORS, AND COUPLERS) BECOME AVAILABLE, IMPLANTABLE BIOSENSORS WILL BE PRACTICAL. APPLICATIONS FOR THESE BIOSENSORS INCLUDE: CONTINUOUS DRUG MONITORING IN INTENSIVECARE; FEEDBACK CONTROL SYSTEMS; AND MEASUREMENT OF TOXIC CHEMICALS IN THE ENVIRONMENT.

Principal Investigator:

Evangeline yap cesar
PRINCIPAL INVESTIGATOR
3137644118

Business Contact:

Small Business Information at Submission:

Michigan Research Corp
2901 Baxter Road Ann Arbor, MI 48109

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No