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CHEMOPREVENTIVE AGENTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4807
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4807
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Microbiological Associates Inc
9900 Blackwell Road Rockville, MD 20850
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: CHEMOPREVENTIVE AGENTS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE OVERALL GOAL OF THIS STUDY IS THE DEVELOPMENT OF TWO IN VITRO TRANSFORMATION ASSAYS FOR THE EVALUATION OF CHEMO- PREVENTIVE AGENTS. THE TWO SYSTEMS UTILIZE PRIMARY SYRIAN HAMSTER EMBRYO CELLS AND RETROVIRAL-INFECTED FISCHER RAT EMBRYO CELLS (A CONTINUOUS CELL CULTURE). BOTH CELL TYPES ARE ROUTINELY TRANSFORMED BY CARCINOGENIC CHEMICALS WITH THEANCHORAGE-INDEPENDENT GROWTH ENDPOINT ASSOCIATED WITH TUMORIGENICITY. MODEL CHEMOPREVENTIVE AGENTS (INHIBITORS OFPROSTAGLANDIN SYNTHESIS AND PROTEASE INHIBITORS) WILL BE USED TO INHIBIT TRANSFORMATION BY CHEMICAL CARCINOGENS. CONDITIONS FOR MAXIMUM EFFECTIVENESS OF THE SELECTED CHEMO- PREVENTIVE AGENTS WILL BE ESTABLISHED DURING THIS PHASE I PROJECT. DURING PHASE II, THE USE OF FLUORESCENT ANTIBODIESTO ONCOGENE PRODUCTS WILL BE INVESTIGATED AS A MEANS OF DETECTING THE EMERGENCE OF MALIGNANT CELLS EARLIER THAN IS SEEN BY COLONY FORMATION IN SOFT AGAROSE. THIS WILL ALLOW MORE EFFECTIVE MEANS OF EVALUATING CHEMOPREVENTIVE AGENTS.

Principal Investigator:

Ronald raineri
PRINCIPAL INVESTIGATOR
3016543400

Business Contact:

Small Business Information at Submission:

Microbiological Associates Inc
5221 River Road Bethesda, MD 20816

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No