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3D Virtual Slide System for Creation and Analysis of Focusable Digital Slides

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
80647
Program Year/Program:
2007 / SBIR
Agency Tracking Number:
MH076188
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MICROBRIGHTFIELD, INC.
185 ALLEN BROOK LN, STE 201 WILLISTON, VT -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2007
Title: 3D Virtual Slide System for Creation and Analysis of Focusable Digital Slides
Agency: HHS
Contract: 2R44MH076188-02A1
Award Amount: $1,520,540.00
 

Abstract:

DESCRIPTION (provided by applicant): Rigorous quantification methods of histological specimens have become a keystone in modern neuroscience such as investigations of neurogenesis, stem cell research, neurotransplantation, neurotoxicology, and the pathogen esis of neurodegenerative and neuropsychiatric diseases. Methods in current practice are not conducive to high-throughput studies because they are often manual and laborious to perform. There is a noticeable lack of computerized automated 3D quantitative h istological analysis tools which can operate on large 3D image volumes. Furthermore, the widespread use of fluorescently labeled tissue sections imposes other limitations, particularly fading of fluorescent dyes, limited availability and tremendous costs o f high-end confocal microscopes. We propose to develop a commercial system (Biolucida ) to overcome this unsatisfactory situation. The core of Biolucida will be 3D virtual slides, which are digital representations (in X, Y and Z) of tissue specimens imaged through a microscope at the highest optical resolution. We will develop software for the acquisition, automated quantitative histological analysis, viewing, sharing and archiving of 3D virtual slides. As such, the use of Biolucida will fully surmount the aforementioned limitations. Consequently we expect that the launch of Biolucida will revolutionize the quantitative analysis of fluorescently labeled tissue sections in modern neuroscience.

Principal Investigator:

Jacob R. Glaser
8022889290
JGLASER@MICROBRIGHTFIELD.COM

Business Contact:

Susan Hendricks
susan@microbrightfield.com
Small Business Information at Submission:

MICROBRIGHTFIELD, INC.
MICROBRIGHTFIELD, INC. 185 ALLEN BROOK LN, STE 201 WILLISTON, VT 05495

EIN/Tax ID: 521609586
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No