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Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
53205
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
0109462
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MicroFab Technologies Inc
1104 Summit Avenue Suite 110 Plano, TX -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: N/A
Agency: NSF
Contract: 0109462
Award Amount: $100,000.00
 

Abstract:

This Small Business Innovation Research Phase I (SBIR) project will use ink-jet printing technology to fabricate precision biodegradable microspheres, 20-200m in diameter, for sustained-release of bioactive substances. The microspheres will be fabricated at specific diameters, as determined by the application, thereby producing an excellent platform for delivery of drugs, hormones, growth factor, DNA vectors / plasmids, cytokines, and enzymes. For the initial application, the microspheres will incorporate antineoplastic agents, such as taxol, for the treatment of head and neck cancer. The physical parameters of the microspheres will be verified with a scanning electron microscope. Release kinetics profiles of the taxol loaded microspheres will be determined by in vitro pharmacokinetic modeling. Quantification of antineoplastic agent release will be performed by High Performance Liquid Chromatography. Retention of efficacy will be tested by first fabricating the taxol microspheres and then extracting and testing the antineoplastic agent in a cell culture model of squamous cell carcinoma. The intact microspheres will also be tested in a nude mouse model of human squamous cell carcinoma. The commercial applications of this project will be in human therapeutics as an alternative to conventional administration of those drugs that have a short half-life or that cause considerable systemic effects.

Principal Investigator:

Andres Romero
9725788076
aromero@microfab.com

Business Contact:

Donald J. Hayes
President
9725788076
dhayes@microfab.com
Small Business Information at Submission:

MicroFab Technologies Inc.
1104 Summit Ave., Suite 110 Plano, TX 75074

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No