This project will develop a blood-test strip for cholesterol. plasma is separated on the strip from cells by a patented filtration process through a glass fiber fleece, collecting the plasma on a detachable recipient member and eluting it into a liquid reagent. cholesterol esterase (che) and oxidase… More

Acetaminophen and salicylates are contained in over 200 prescription and non-prescriptionformulations. Of all intentional and unintentional overdose ingestions of pharmaceutical andnon-pharmaceutical compounds, those of acetaminophen and salicylates are the most frequent, both innumber of exposures… More

Lipoprotein(a) [Lp(a)] has been labelled the most atherogenic lipoprotein in man. Current laboratorLp(a) employ immuno-quantitation of its apolipoprotein [apo(a)]. Because these methods are hamperedto plasminogen, apo(a) isoform dependence, antibody heterogeneity, and lack of standardization,… More

Not Available Recent discoveries of plant-like organelles in Plasmodium falciparum, the organism that causes malaria, provide potential new avenues toward treatment and prevention of this deadly disease. More specifically, it is now known that the Shikimate Pathway, an enzymatic pathway that… More

DESCRIPTION: (Applicant's abstract) Poisoning from ethylene glycol is a potentially lethal medical emergency but can be treated effectively when recognized early. Conversely, when diagnosis is late, the outcome is usually poor. The major pathogenic factor is… More

DESCRIPTION: (Applicant's abstract) Poisoning from ethylene glycol is a potentially lethal medical emergency but can be treated effectively when recognized early. Conversely, when diagnosis is late, the outcome is usually poor. The major pathogenic factor is… More

DESCRIPTION (Adapted from the Investigator's Abstract): Liver failure is a major cause of death in the U.S. There is a great need for a liver assist device for temporary support of liver failure patients. Algenix is developing a bioartificial liver to meet this critical… More

DESCRIPTION (provided by applicant): Of the 120 million diabetics in the world, one half are undiagnosed and therefore deprived of the proven benefits of tight glucose control in curbing diabetes-related complications. Recognizing this problem the American Diabetes Association and National Diabetes… More

DESCRIPTION (provided by applicant): The applicant organization proposes to develop an ultra-miniaturized, minimally invasive diabetes monitoring system for estimating concentrations of diabetes-related parameters (analytes) in whole blood. The system is comprised of analyte specific test tabs… More

DESCRIPTION (provided by applicant): The applicant organization proposes to develop an ultra-miniaturized, minimally invasive diabetes monitoring system for estimating concentrations of diabetes-related parameters (analytes) in whole blood. The system is comprised of analyte specific test tabs… More

DESCRIPTION (provided by applicant): The applicant organization proposes to develop ultra-miniaturized, minimally invasive test wand methods for quantification in whole blood specimens of methanol, formate, ethylene glycol, and glycolate, the four critical analytes in the laboratory evaluation of… More

DESCRIPTION (provided by applicant): More than half of the world's diabetics and individuals at risk for atherosclerosis due to high blood glucose and lipids (cholesterol, triglyceride) are undiagnosed. A fast growing component of this huge patient population are people with metabolic syndrome. Most… More