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CHOLESTEROL THRESHOLD ASSAY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11327
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
11327
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MICRONIX, INC.
MICRONIX, INC. 14950 GREYHOUND CT, STE 307 CARMEL, IN 46032
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1992
Title: CHOLESTEROL THRESHOLD ASSAY
Agency: HHS
Contract: N/A
Award Amount: $417,683.00
 

Abstract:

THIS PROJECT WILL DEVELOP A BLOOD-TEST STRIP FOR CHOLESTEROL. PLASMA IS SEPARATED ON THE STRIP FROM CELLS BY A PATENTED FILTRATION PROCESS THROUGH A GLASS FIBER FLEECE, COLLECTING THE PLASMA ON A DETACHABLE RECIPIENT MEMBER AND ELUTING IT INTO A LIQUID REAGENT. CHOLESTEROL ESTERASE (CHE) AND OXIDASE (CHOD) ARE INCORPORATED IN DRY FORM ON THE STRIP. QUANTITATION IS BASED ON A THRESHOLD ASSAY FOR PEROXIDE GENERATED BY CHE AND CHOD. THE ASSAY COMPRISES A SCAVENGER AND A SIGNAL REACTION. THE BELOW-THRESHOLD AMOUNT OF PEROXIDE, EQUIVALENT TO THE 200 MG/DL CHOLESTEROL CUTOFF RECENTLY SUGGESTED BY THE NATIONAL HEART, LUNG, AND BLOOD INSTITUTE, IS REACTED IN THESCAVENGER, THE ABOVE-THRESHOLD AMOUNT IN THE SIGNAL REACTION. THUS, BY ELIMINATION OF LARGE COLOR BACKGROUNDS AND BY CHOOSING HIGHLY SENSITIVE SIGNAL REACTIONS, VISUAL INTERPRETATION IS GREATLY ENHANCED. THE DEVICE DOES NOT REQUIRE AN INSTRUMENT, MAKING IT ECONOMICAL AND FAST FOR MASS SCREENINGS AND SELF-MONITORING. FEASIBILITY OF THE TEST PRINCIPLE HAS BEEN DEMONSTRATED FOR PEROXIDE AND CHOLESTEROL FROM SERUM. THIS RESEARCH WILL INCLUDE THE FINAL SELECTION OF OPTIMAL PLASMA SEPARATION AND RECIPIENT MEMBER MATERIALS, OPTIMIZATION OF THE REAGENT SYSTEM, AND THE MANUFACTURE OF FUNCTIONAL PROTOTYPE TEST STRIPS CAPABLE OF DIFFERENTIATING CONCENTRATION INTERVALS OF BETWEEN 10 AND 20 MG/DL AROUND THE 200 MG/DL CUTOFF LEVEL.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Micronix
10930 Braewick Dr Carmel, IN 46032

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No