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Rapid Teststrip Assay for Acetaminophen and Salicylate

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
25092
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
25092
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MICRONIX, INC.
MICRONIX, INC. 14950 GREYHOUND CT, STE 307 CARMEL, IN 46032
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1995
Title: Rapid Teststrip Assay for Acetaminophen and Salicylate
Agency: HHS
Contract: 1 R43 GM50606-1,
Award Amount: $749,603.00
 

Abstract:

Acetaminophen and salicylates are contained in over 200 prescription and non-prescriptionformulations. Of all intentional and unintentional overdose ingestions of pharmaceutical andnon-pharmaceutical compounds, those of acetaminophen and salicylates are the most frequent, both innumber of exposures and fatalities. Many exposures are co-intoxications of both drugs. Approximatelyone half of all patients are children. The need for rapid estimation of acetaminophen and salicylates inacute intoxication and therapeutic monitoring is well documented. Rapid test methods for use bynon-laboratory personnel in emergency and point-of-care environments are currently unavailable. Somelaboratory spot-tests for urine exist but they lack specificity, and timely specimen acquisition, transferand analysis can be problematic. Available methods on automated instruments and compact analyzersare scarce and cost-intensive. We will develop of a novel non-instrumented dual-analyte teststripmethod for the rapid simultaneous semi-quantitation of acetaminophen and salicylates from unmeasuredmicro-specimens of whole blood, saliva and urine. The method is specific for each of the two drugs asenzymic-calorimetric detection principles are employed. Dry reagent technology enhances methodstability and product life time. Contributions of the devices are its functionality in a near-patient,non-laboratory environment, early detection, timely institution of treatment, and cost-savings.

Principal Investigator:

Hans Kloepfer
3178424939

Business Contact:

Small Business Information at Submission:

Micronix
6856 Hawthorne Park Drive Indianapolis, IN 46220

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No