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Method for Isolation and Microassay of Lipoprotein (A)

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29570
Program Year/Program:
1997 / SBIR
Agency Tracking Number:
29570
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MICRONIX, INC.
MICRONIX, INC. 14950 GREYHOUND CT, STE 307 CARMEL, IN 46032
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1997
Title: Method for Isolation and Microassay of Lipoprotein (A)
Agency: HHS
Contract: 1 R43 HL55111-01,
Award Amount: $592,416.00
 

Abstract:

Lipoprotein(a) [Lp(a)] has been labelled the most atherogenic lipoprotein in man. Current laboratorLp(a) employ immuno-quantitation of its apolipoprotein [apo(a)]. Because these methods are hamperedto plasminogen, apo(a) isoform dependence, antibody heterogeneity, and lack of standardization, noneapproved. One third of Lp(a)'s mass is cholesterol, and only one tenth is apo(a). We will develop olaboratory, and a semi-quantitative screening method for Lp(a) cholesterol [Lp(a)-C]. The methods exhigh content of carbohydrate, e.g. sialic acid. Lp(a) is separated from other lipoproteins by bindincarbohydrate structures to a specific solid-supported lectin, and analyzed by highly sensitive enzym

Principal Investigator:

Mary Gaunt Kloepfer
31775

Business Contact:

Small Business Information at Submission:

Micronix
6856 Hawthorne Park Drive Indianapolis, IN 46220

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No