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NOVEL ASSAY METHODS FOR ETHYLENE GLYCOL TOXICITY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
45975
Program Year/Program:
1999 / SBIR
Agency Tracking Number:
1R43GM060076-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MICRONIX, INC.
MICRONIX, INC. 14950 GREYHOUND CT, STE 307 CARMEL, IN 46032
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1999
Title: NOVEL ASSAY METHODS FOR ETHYLENE GLYCOL TOXICITY
Agency: HHS
Contract: N/A
Award Amount: $99,510.00
 

Abstract:

Not Available Recent discoveries of plant-like organelles in Plasmodium falciparum, the organism that causes malaria, provide potential new avenues toward treatment and prevention of this deadly disease. More specifically, it is now known that the Shikimate Pathway, an enzymatic pathway that provides essential aromatics, is vital to the survival of P. falciparum. By blocking any of the seven enzymes in this pathway, it is possible to attenuate growth of the organism. Since these enzymes are not present in humans, their blockage presents an opportunity to effectively and selectively treat the disease without harm to human cells. We propose to clone the recently discovered P. falciparum charismata synthase (enzyme #7 of the Shikimate pathway) in E. Coli, by known procedures. Using the resulting product, we will then develop a prototype high throughput assay, which will lead to the development (in Phase II) of a major screening program of combinatorial libraries of potential antimalarial drugs. BENEFITS: Safe and effective antimalarials could make a significant impact in human health. The proposed genomics/combinatorial chemistry approach not only provides potential new antimalarials, but validates a method of much broader application to drug discovery.

Principal Investigator:

Hans G. Kloepfer

Business Contact:


3178444324
MICRONIX@MCIWORLD.COM
Small Business Information at Submission:

MICRONIX, INC.
14950 GREYHOUND CT, STE307 CARMEL, IN 46032

EIN/Tax ID: 389427111
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No