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Company Information:

Name: Epoch Pharmaceuticals, Inc.
Address: 1725 220TH ST SE, 104
Bothell, WA 98052
Located in HUBZone: No
Woman-Owned: No
Minority-Owned: No
URL: N/A
Phone: (425) 881-7600

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,522,022.00 25
SBIR Phase II $4,891,705.00 10

Award List:

IN MAN

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: HHS
Principal Investigator: Dennis e schwartz , PRINCIPAL INVESTIGATOR
Award Amount: $50,000.00
Abstract:
In this project, synthetic short dna probes will be developed for the diagnosis of specific types of human papillomavirus (hpv) infections. short dna probes of 20 to 30 nucleotides have the desirable properties of high specificity, fast reaction kinetics, potential high sensitivity, and the ability… More

A DNA PROBE FOR THE DIAGNOSIS OF CAMPYLOBACTER PYLORIDIS GASTRITIS

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: HHS
Principal Investigator: Dennis E Schwartz , Principal Investigator
Award Amount: $50,000.00

DNA PROBES FOR THE DIAGNOSIS OF PERIODONTAL PATHOGENS

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: HHS
Principal Investigator: Dennis E Schwartz , Principal Investigator
Award Amount: $42,000.00

SYNTHETIC OLIGONUCLEOTIDES FOR TRYPANOSOME CHEMOTHERAPY

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: Dennis E Schwartz Phd
Award Amount: $50,000.00

DNA PROBES TO DETECT HUMAN PAPILLOMAVIRUS IN ORAL CANCER

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: Dennis E Schwartz Phd
Award Amount: $49,000.00

DNA PROBES FOR THE DIAGNOSIS OF BACTERIAL VAGINOSIS

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: Diana K Sheiness Phd
Award Amount: $47,000.00

CROSS-LINKING OLIGONUCLEOTIDES FOR CHEMOTHERAPY

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: Rich B Meyer Jr Phd
Award Amount: $50,000.00

DNA PROBES FOR THE DIAGNOSIS OF PERIODONTAL PATHOGENS

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: HHS
Principal Investigator: Dennis E Schwartz , Principal Investigator
Award Amount: $485,000.00
Abstract:
The role of specific bacteria as the etiologic agents of gingivitis and periodontitis is supported by a growing scientific literature. however, conventional micro- biological techniques have restricted advances in disease diagnosis and monitoring. the purpose of this phase i project is to develop… More

A DNA PROBE FOR THE DIAGNOSIS OF CAMPYLOBACTER PYLORIDIS GASTRITIS

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: HHS
Principal Investigator: Dennis E Schwartz , Principal Investigator
Award Amount: $487,000.00
Abstract:
The role of a specific bacterium as the possible etiologic agent of gastritis or peptic ulcer is supported by a growingscientific literature. however, the difficulty of convent- ional sampling and diagnostic techniques has restricted advances in disease diagnosis. the purpose of this phase i project… More

DNA PROBES TO DETECT HUMAN PAPILLOMAVIRUS IN ORAL CANCER

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: HHS
Principal Investigator: Dennis E Schwartz Phd
Award Amount: $500,000.00
Abstract:
In situ dna-probe hybridization assays will be used to determine the types of human papillomavirus (hpv) associatedwith oral cancers. short, synthetic dna probes, specific for hpv types 6, 11, 16, 18, and 31, will be tested on thin sections of tumor specimens from the archives of the division of… More

DNA PROBES TO DETECT PREDISPOSITION TO TYPE I DIABETES

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00
Abstract:
Insulin-dependent diabetes mellitus (type i) occurs in about0.5% of caucasians. the incidence increases over 20-fold inindividuals with the specific susceptibility gene hla-dq3.2. approximately 70% of individuals who become insulin-dependent diabetics carry this gene, making it the most specific… More

CHEMOTHERAPY OF LEISHMANIA WITH OLIQODEOXYNUCLEOTIDE PROBES

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Dr Rich B Meyer Jr
Award Amount: $49,993.00

SYNTHETIC OLIGONUCLEOTIDES FOR TRYPANOSOME CHEMOTHERAPY

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: HHS
Principal Investigator: Dennis E Schwartz Phd
Award Amount: $490,442.00
Abstract:
The 5' ends of all trypanosome mrnas have recently been shown to have a common 35-nucleotide spliced leader (sl). the sl is believed to arise by transcription within a mini-exon-derived rna (medrna) of about 140 nucleotides, followed by its trans-splicing with the primary transcripts of mrnas. the… More

DNA PROBES FOR THE DIAGNOSIS OF BACTERIAL VAGINOSIS

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: HHS
Principal Investigator: Diana K Sheiness Phd
Award Amount: $499,906.00
Abstract:
The role of five bacteria and a mycoplasma as the etiologic agents of bacterial vaginosis (bv) is supported by growing scientific data. standard methods are inadequate for the routine diagnosis of this disease. eight hundred to 1,000 nucleotides of the 16s ribosomal rna (rrna) of each bv… More

CROSS-LINKING OLIGONUCLEOTIDES FOR CHEMOTHERAPY

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: HHS
Principal Investigator: Rich B Meyer Jr Phd
Award Amount: $412,000.00
Abstract:
Short oligodeoxynucleotides incorporating nucleotides modified by the addition of reactive cross-linking arms willbe synthesized. these oligonucleotides should hybridize with target sequences in mrna or dna and, once bound, shouldcovalently cross-link with the complementary sequence via the… More

RETROVIRUS MODEL--EVUALUATE ANTI-SENSE PROBE THERAPY

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00
Abstract:
Viral or plasmid constructs containing a human growth hormone (hgh) gene positioned downstream from an authentic viral or host transcriptional control sequence should provide a convenient system in which to rapidly and quantitatively evaluate antisense oligonucleotides directed toward leader rna.… More

DNA AND RNA EXTRACTIONFROM FECES FOR DNA PROBE ANALYSIS

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $49,991.00
Abstract:
Nucleic acids can be rapidly and efficiently extracted from aqueous solutions into butanol containing a cationic detergent. subsequently, these nucleic acids can be transferred from the cationic detergent/butanol phase into a second aqueous phase containing high concentrations of salt. nucleic acids… More

CHEMOTHERAPY OF LEISHMANIA WITH OLIQODEOXYNUCLEOTIDE PROBES

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Dr Rich B Meyer Jr
Award Amount: $563,537.00
Abstract:
We will investigate the ability of oligodeoxynucleotides complementary to the spliced leader sequence of leishmania enriettii tubulin mrna's to inhit translation and to kill the cells in culture. various chemical modifications will be made to enhance the effect of the oligos. successful agents may… More

DNA PROBE TEST TO DETECT ORAL CANDIDA IN AIDS PATIENTS

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Diana K Sheiness
Award Amount: $49,988.00
Abstract:
This research will provide the foundation for a rapid, inexpensive, non-culture-based test for the quantitative detection of oral candida albicans in hiv-positive patients. the primary experimental objective is to create a set of short synthetic oligodeoxynucleotide probes that will hybridize… More

NUCLEAR TARGETING OF OLIGONUCLEOTIDE-PEPTIDE CONJUGATES

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael W Reed
Award Amount: $49,981.00

NOVEL, SPECIFIC NUCLEIC ACID CLEAVAGE AGENTS

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Reed, Michael W , Principal Investigator
Award Amount: $50,000.00
Abstract:
In this phase i study we will improve the efficiency and develop the linking chemistry of a novel class of dna cleavage reagents. these agents, which undergo thermally triggered radical formation will be modified with an intercalating group in order to increase the efficiency of dna cleavage. the… More

HIV REPORTER CELL LINE FOR SCREENING ANTI-SENSE AGENTS

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gamper, Howard B , Principal Investigator
Award Amount: $50,000.00
Abstract:
A secretable alkaline phosphatase (spap) reporter gene will be substituted for a portion of the env gene in an hiv proviral dna clone. expression of the reporter gene will be regulated by a complete complement of viral cis and trans acting control elements, such that the level of extracellular… More

ANTI-SENSE INHIBITION OF HBSAG EXPRESSION IN HEP G2 CELL

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gamper, Howard B , Principal Investigator
Award Amount: $49,936.00
Abstract:
Uniquely modified anti-sense oligodeoxynucleotides (odns) targeted to the hepatitis b surface antigen transcript will be evaluated in a differentiated hepatoma cell line which supports the constitutive production of infectious dane particles. inhibition of surface antigen production will be… More

NUCLEAR TARGETING OF OLIGONUCLEOTIDE-PEPTIDE CONJUGATES

Award Year / Program / Phase: 1992 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael W Reed
Award Amount: $499,629.00
Abstract:
This phase i study will explore the therapeutic possibilities of antisense oligodeoxynucleotides that have been covalently conjugated to signal peptides that can direct the transport of proteins into the nucleus. in recent years, 16 peptide sequences with nuclear targeting properties have been… More

SIMULTANEOUS DETECTION OF N. GONORRHOEAE AND C. TRACHOMATIS

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Charles R Petrie
Award Amount: $50,000.00
Abstract:
Neisseria gonorrhoeae and chlamydia trachomatis cause urethritis in males and mucopurulent cervicitis in females. a device distinguishing these pathogens concurrently in a single test would greatly enhance diagnosis of this disease syndroms. oligodeoxynucleotide probes specificfor each organism have… More

DNA PROBES TO DETECT PREDISPOSITION TO TYPE I DIABETES

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Nicolaas M J Vermeulen
Award Amount: $47,745.00

Probes for Metabolic Markers Of Antibiotic Resistance

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerard Cangelosi
Award Amount: $48,220.00

DNA PROBES TO DETECT PREDISPOSITION TO TYPE I DIABETES

Award Year / Program / Phase: 1994 / SBIR / Phase II
Agency: HHS
Principal Investigator: Nicolaas M J Vermeulen
Award Amount: $470,000.00
Abstract:
Insulin-dependent diabetes mellitus (type i) occurs in about 0.5% of caucasians. the incidence increases over 20-fold in individuals with the speific susceptibility gene hla-dq3.2. approximately 70% of individuals who become insulin-dependent diabetics carry this gene, making it the most specific… More

Probes for Metabolic Markers Of Antibiotic Resistance

Award Year / Program / Phase: 1994 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerard Cangelosi
Award Amount: $484,191.00
Abstract:
The aim is to evaluate a novel technology for testing the susceptibility of prokaryotes to certain antibiotics. Our goal is to develop rapid antibiotic susceptibility tests for Mycobacterium tuberculosis and other pathogens. The technology will rapidly detect growth of resistant bacteria challenged… More

DNA Probe Detection of Oral Spirochetes

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Paul Haydock
Award Amount: $98,307.00
Abstract:
Treponema denticola is an oral spirochete associated with periodontal disease. T. denticola belongsfamily of oral spirochetes which, although found in low numbers in healthy tissue, increases in numbOral treponemes have the ability to invade gingival and connective tissues by mechanisms which are… More

Biochemistry of Oligomer/Pyrroloindole Conjugates

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Igor Kutyavin
Award Amount: $93,147.00
Abstract:
We have developed the chemistry to conjugate a pyrroloindole tripeptide (CDPI3) analog of CC-1065 t3' ends of any oligodeoxyribonucleotide (ODN). The resultant conjugates hybridize sequence specificaDNA and RNA strands, yet do not interact with double-stranded DNA. The conjugated CDPI3 moiety can… More

ANTIBIOTIC SUSCEPTIBILITY TESTING FOR ORAL BACTERIA

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $97,762.00

RAPID AUTOMATED DNA PROBE DIAGNOSTIC TEST FOR MALARIA

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $98,952.00

LOW COST HIV DRUG RESISTANCE MONITORING

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: U'ren, jack r
Award Amount: $100,000.00

SELECTIVELY BINDING COMPLEMENTARY OLIGONUCLEOTIDES

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Wydro, robert
Award Amount: $100,000.00