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DNA PROBES TO DETECT HUMAN PAPILLOMAVIRUS IN ORAL CANCER

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7154
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
7154
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Epoch Pharmaceuticals, Inc.
1725 220TH ST SE, 104 Bothell, WA 98052
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1988
Title: DNA PROBES TO DETECT HUMAN PAPILLOMAVIRUS IN ORAL CANCER
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

IN SITU DNA-PROBE HYBRIDIZATION ASSAYS WILL BE USED TO DETERMINE THE TYPES OF HUMAN PAPILLOMAVIRUS (HPV) ASSOCIATEDWITH ORAL CANCERS. SHORT, SYNTHETIC DNA PROBES, SPECIFIC FOR HPV TYPES 6, 11, 16, 18, AND 31, WILL BE TESTED ON THIN SECTIONS OF TUMOR SPECIMENS FROM THE ARCHIVES OF THE DIVISION OF ORAL PATHOLOGY, UNIVERSITY OF WASHINGTON. THE SPECIMENS WILL INCLUDE PAPILLOMAS AND FRANK CARCINOMAS. THIS STUDY WILL DEMONSTRATE THE FEASIBILITY OF ROUTINE TESTING OF ORAL BIOPSIES FOR HPV INFECTION BY IN SITU HYBRIDIZATION AND MAY PROVIDE NEW INFORMATION REGARDING THE SPECIFIC TYPES OF HPV ASSOCIATED WITH ORAL MALIGNANCY. IN ADDITION, THIS STUDY WILL DIRECTLY COMPARE THE EFFICACY OF LONG, CLONED DNA PROBES AND SHORT, SYNTHETIC DNA PROBES IN IN SITU DNA HYBRIDIZATIONS. THE RESULTS OF THIS PROJECT WILL BE IMPORTANT FOR THE COMMERCIAL DEVELOPMENT OF NONISOTOPIC. DNA PROBE-BASED DIAGNOSTIC SYSTEMS FOR USE IN CLINICAL AND ORAL PATHOLOGY LABORATORIES.

Principal Investigator:

Dennis E Schwartz Phd
2064858566

Business Contact:

Small Business Information at Submission:

Microprobe Corp.
1725 220th St Southeast #104 Bothell, WA 98021

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No