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NOVEL, SPECIFIC NUCLEIC ACID CLEAVAGE AGENTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16634
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
16634
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Epoch Pharmaceuticals, Inc.
1725 220TH ST SE, 104 Bothell, WA 98052
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1991
Title: NOVEL, SPECIFIC NUCLEIC ACID CLEAVAGE AGENTS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

IN THIS PHASE I STUDY WE WILL IMPROVE THE EFFICIENCY AND DEVELOP THE LINKING CHEMISTRY OF A NOVEL CLASS OF DNA CLEAVAGE REAGENTS. THESE AGENTS, WHICH UNDERGO THERMALLY TRIGGERED RADICAL FORMATION WILL BE MODIFIED WITH AN INTERCALATING GROUP IN ORDER TO INCREASE THE EFFICIENCY OF DNA CLEAVAGE. THE THERMAL CLEAVERS CAN BE PREPARED USING WELL ESTABLISHED SYNTHETIC ROUTES WHICH PROVIDE READY ACCESS TO A WIDE VARIETY OF DERIVATIVES. THE LENGTH OF THE LINKER ARM BETWEEN THE INTERCALATOR AND THE CLEAVER WILL BE OPTIMIZED WITH THE AID OF COMPUTER ASSISTED MOLECULAR DESIGN. EFFICIENCY OF CLEAVAGE WILL BE EXAMINED UNDER A VARIETY OF TEMPERATURES AND REACTION CONDITIONS. ANOTHER AIM OF THIS PHASE I STUDY IS TO PREPARE THERMALLY TRIGGERED CLEAVAGE AGENTS WITH ELECTROPHILIC GROUPS CAPABLE OF REACTION WITH NUCLEOPHILIC OLIGONUCLEOTIDES. THE REACTION OF THESE HIGHLY REACTIVE COMPOUNDS WITH MODEL NUCLEOPHILES WILL BE EXAMINED. THESE EXPERIMENTS CONSTITUTE A FEASIBILITY STUDY FOR THE DEVELOPMENT OF THE THERMALLY TRIGGERED CLEAVAGE AGENTS AS OLIGONUCLEOTIDE TARGETED AFFINITY CLEAVAGE AGENTS (PHASE II).

Principal Investigator:

Reed, Michael W
Principal Investigator
2064858566

Business Contact:

1 r43 gm46143-01
Small Business Information at Submission:

Microprobe Corpon
1725 220th Street Se, #104 Bothell, WA 98021

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No