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DNA Probe Detection of Oral Spirochetes

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29351
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29351
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Epoch Pharmaceuticals, Inc.
1725 220TH ST SE, 104 Bothell, WA 98052
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: DNA Probe Detection of Oral Spirochetes
Agency: HHS
Contract: 1 R43 DE11218-01A1,
Award Amount: $98,307.00
 

Abstract:

Treponema denticola is an oral spirochete associated with periodontal disease. T. denticola belongsfamily of oral spirochetes which, although found in low numbers in healthy tissue, increases in numbOral treponemes have the ability to invade gingival and connective tissues by mechanisms which are nunderstood. Since routine culture of these organisms is difficult, the most commonly used method ofpresence of oral spirochetes is dark field microscopy of wet mounts, a method not readily adaptablepractice. It is our aim to develop DNA probes directed to T. denticola, the newly identified PathogeSprochete (PROS), and other oral spirochetes and to incorporate these probes into a semi-automated aIn Phase I of this project, DNA probes will be developed and tested. In Phase II, the assay incorporbe characterized and tested in actual patient populations to determine which probe is most informatipatient care. This assay will ultimately provide a simple chair-side means of detecting the presenceallowing for patient risk assessment and treatment efficacy.

Principal Investigator:

Paul Haydock
20685

Business Contact:

Small Business Information at Submission:

Microprobe Corp.
1725 220th Street SE, 104 Bothell, WA 98021

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No