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Biochemistry of Oligomer/Pyrroloindole Conjugates

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29455
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29455
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Epoch Pharmaceuticals, Inc.
1725 220TH ST SE, 104 Bothell, WA 98052
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Biochemistry of Oligomer/Pyrroloindole Conjugates
Agency: HHS
Contract: 1 R43 GM52774-01A1,
Award Amount: $93,147.00
 

Abstract:

We have developed the chemistry to conjugate a pyrroloindole tripeptide (CDPI3) analog of CC-1065 t3' ends of any oligodeoxyribonucleotide (ODN). The resultant conjugates hybridize sequence specificaDNA and RNA strands, yet do not interact with double-stranded DNA. The conjugated CDPI3 moiety can sstabilize short duplexes by binding to the minor groove. In light of these results, we will evaluateconjugates as anti sense and antigene agents. The ability of ODN-CDPI3 conjugates to sequence specifreplication, transcription and translation will be investigated using simple in vitro model systems.studies will be initiated to evaluate the potential of these modified ODNs for use as anti sense, anagents.

Principal Investigator:

Igor Kutyavin
20685

Business Contact:

Small Business Information at Submission:

Microprobe Corp.
1725 220th Street SE, 104 Bothell, WA 98021

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No