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ORIENTED PROTEIN MICROARRAY FOR FUNCTIONAL STUDIES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60104
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
RR017130
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MICROSURFACES INC
3913 Todd Lane SUITE 102 Austin, TX 78744-
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Woman-Owned: Yes
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: ORIENTED PROTEIN MICROARRAY FOR FUNCTIONAL STUDIES
Agency: HHS
Contract: 1R43RR017130-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant):A novel method is proposed for the fabrication of protein microarrays using metal coordination chemistry and poly-histidine tagged protein molecules. The proposed method is aimed at microarrays with highly selective and facile linking chemistry, with uniform and controllable orientation of immobilized protein molecules, and with proteins in native states and easily accessible by targets in the solution. Preliminary experiments using 6x-His terminated green-fluorescence protein (GFP) demonstrated the feasibility and potential of the proposed approach. We will establish the advantage of an oriented protein microarray in protein-ligand interaction studies over randomly oriented arrays fabricated by existing methods. We also propose to explore protein immobilization without purification on the highly selective metal ion surface. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

Principal Investigator:

Athena Guo
7637880255
ATHENA@MEMSURFACE.COM

Business Contact:

Athena Guo
7637880255
ATHENA@MEMSURFACE.COM
Small Business Information at Submission:

MICROSURFACES, INC.
MICROSURFACES, INC. 4220 CENTRAL AVE NE, STE 101 MINNEAPOLIS, MN 55421

EIN/Tax ID: 411991341
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No