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Laser Tweezer Based Instrument for Cell Biology Research

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
76385
Program Year/Program:
2005 / STTR
Agency Tracking Number:
NS052023
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MINOTAUR TECHNOLOGIES, LLC
MINOTAUR TECHNOLOGIES, LLC 535 W. Research Blvd., Suite 135, M/S 600 FAYETTEVILLE, AR 72701
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Laser Tweezer Based Instrument for Cell Biology Research
Agency: HHS
Contract: 1R41NS052023-01
Award Amount: $150,000.00
 

Abstract:

DESCRIPTION (provided by applicant): The proposed project is to develop an instrument for cell biology research based on a technique for perturbing local cytosolic concentrations of key signal transduction mediators with sustainable submicrometer resolution. In this technique, microspheres are decorated with selected enzymes, creating high local concentrations of an effector at the particle surface. Laser tweezers are used to manipulate these particles in a cell. The Phase I project will prove the feasibility of implementing the optical trapping system based on waveform modulation and demonstrate the effectiveness of the technique using a relatively low-cost diode laser in place of the titanium sapphire laser used in preliminary work. Successful application of the technology will have broad implications. Most importantly, it would provide a means for effecting local cytosolic properties over timescales much greater (e.g., hours) than cell biologists currently are able to achieve using techniques such as focal uncaging and electrophysiological techniques, both of which typically result in broad cellular distribution of effectors within milliseconds to seconds due to diffusion. The proposed instrument will provide the capability to directly deliver a biochemical, pharmacophore or protein of choice to any site within a cell and thereby constitutes a tremendous technological advance for the biomedical research field.

Principal Investigator:

Dorel Guzun
4795712592
DGUZUN@VIRTUAL-INCUBATION.COM

Business Contact:

Calvin Goforth
4795712592
cgoforth@VIRTUAL-INCUBATION.COM
Small Business Information at Submission:

Minotaur Technologies, LLC
535 W. Research Blvd. Suite 135, M/S 600 Fayetteville, AR 72701

EIN/Tax ID: 412118216
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIVERSITY OF TEXAS
UNIVERSITY OF TEXAS HLTH SCI CTR
BOX 20036
HOUSTON, TX 77225
RI Type: Nonprofit college or university