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SINCE JUNE, 1981, OVER 700 CASES OF AIDS HAVE BEEN REPORTED TO THE CENTERS FOR…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
1360
Program Year/Program:
1984 / SBIR
Agency Tracking Number:
1360
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Molecular Biosystems Inc
10030 Barnes Canyon Rd San Diego, CA 92121
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1984
Title: SINCE JUNE, 1981, OVER 700 CASES OF AIDS HAVE BEEN REPORTED TO THE CENTERS FOR DISEASE CONTROL.
Agency: HHS
Contract: N/A
Award Amount: $42,286.00
 

Abstract:

SINCE JUNE, 1981, OVER 700 CASES OF AIDS HAVE BEEN REPORTED TO THE CENTERS FOR DISEASE CONTROL. MOST CASES HAVE INVOLVED HOMOSEXUAL OR BISEXUAL MEN; THE REMAINDER INVOLVED HETEROSEXUAL MEN AND WOMEN, HAITIANS, AND INTRAVENOUS DRUG ABUSERS. THE ETIOLOGY OF THE DISEASE IS PROBABLY A VARIOUSLY TRANSMITTED BIOLOGICAL AGENT. PATIENTS WITH AIDS HAVE EVIDENCE OF CELLULAR IMMUNODEFICIENCY WITH CUTANEOUS ENERGY, REDUCED NUMBERS AND ALTERED PROPORTIONS OF T-LYMPHOCYTES, AND IMPAIRED LYMPHOCYTE TRANSFORMATION. OPPORTUNISTIC INFECTIONS AND KAPOSI'S SARCOMA OCCURRING IN THESE PATIENTS ARE LIKELY DUE TO ACQUIRED IMMUNODEFICIENCY ANALOGOUS TO TREATMENT WITH IMMUNOSUPPRESSIVE DRUGS. A GENETIC DEFICIENCY OF ADENOSINE DEAMINASE (ADA) HAS BEEN CAUSALLY ASSOCIATED WITH SEVERE COMBINED IMMUNODEFICIENCY DISEASE (SCIDS). PATIENTS WITH ADA DEFICIENCY ARE SUBJECT TO RECURRING, CHRONIC VARIED INFECTIONS TO WHICH THEY OFTEN SUCCUMB. MANY HAVE NO DETECTABLE LYMPHOCYTES IN PERIPHERAL BLOOD OR BONE MARROW. CELL MEDIATED IMMUNITY IS SEVERELY IMPAIRED. T-CELLS DEFINED BY E ROSETTES ARE OFTEN ABSENT AND LYMPHOCYTE PROLIFERATIVE RESPONSES ARE SEVERELY LIMITED. GIVEN THE CLOSE CLINICAL RESEMBLANCE BETWEEN AIDS AND SCIDS, WE PROPOSE TO MEASURE ADA LEVELS IN ERYTHROCYTES OF 20 TO 30 AIDS PATIENTS IN ORDER TO DETERMINE WHETHER A CLINICAL MANIFESTATION OF THE DISEASE PROCESS IS ASSOCIATED WITH A DEFICIENCY OF ADA. WE PROPOSE, DURING PHASE I, TO DETERMINE WHETHER OR NOT THERE IS AN ADA DEFICIENCY IN CIRCULATING ERYTHROCYTES OF AIDS PATIENTS. IF SO, WE PLAN TO EXPAND THE STUDY IN PHASE II AND ALSO DEVELOP A CONVENIENT ASSAY FOR ADENOSINE DEAMINASE AS PART OF A RAPID SCREENING TEST FOR AIDS.

Principal Investigator:

Kenneth j. widder
CHAIRMAN
0

Business Contact:

Small Business Information at Submission:

Molecular Biosystems Inc.
11180 Roselle Street Suite A San Diego, CA 92121

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No