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TOPICAL PRODRUGS FOR THE TREATMENT OF PSORIASIS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7907
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
7907
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MOLECULAR DESIGN INTERNATIONAL, INC.
111 South Highland Street MEMPHIS, TN 38111-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1991
Title: TOPICAL PRODRUGS FOR THE TREATMENT OF PSORIASIS
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

PSORIASIS IS A DISEASE THAT AFFECTS MILLIONS OF AMERICANS WITH CHRONIC RECURRENT EXACERBATIONS AND REMISSIONS THAT AREEMOTIONALLY AND PHYSICALLY DEBILITATING. SEVERAL TREATMENTSARE AVAILABLE, BUT IN MANY CASES THESE ARE INADEQUATE. THIS APPLICATION IS BASED ON THE PREMISE THAT TOPICAL ADMINISTRATION OF PRODRUGS SHOULD RESULT IN HIGH CONCENTRATIONS OF THE ACTIVE DRUG AT THE LESION SITE WITH LOWER CONCENTRATIONS SYSTEMICALLY. LESS TOTAL DOSE COULD BE USED THAN WITH ORAL ADMINISTRATION. THE EFFICACY OF THE DRUG MIGHT BE MAINTAINED AT THIS LOWER DOSE; THUS, TOPICAL PRODRUGS MIGHT LEAD TO SAFER PRODUCTS. WE PROPOSE TO DESIGN, SYNTHESIZE AND TEST TOPICAL PRODRUGS OF SOME OF THE EFFECTIVE SYSTEMIC DRUGS FOR PSORIASIS, PLUS SOME COMPOUNDS WHOSE POTENTIAL EFFICACY IS PREDICTED FROM A BIOCHEMICAL UNDERSTANDING OF PSORIASIS. THERE IS A SUBSTANTIAL VOLUME OF LITERATURE ON THE PATHOPHYSIOLOGY OF PSORIASIS AND THE THERAPEUTIC POTENTIAL OF LIPOXYGENASE INHIBITORS. SINCE THERE IS NO ANIMAL MODEL FOR PSORIASIS, THE BIOLOGICALTESTING WILL BE DONE WITH THE ARACHIDONIC ACID MOUSE EAR MODEL DESIGNED TO TEST LIPOXYGENASE INHIBITORS. IF THIS PHASE I PROJECT IS SUCCESSFUL, PHARMACOLOGICAL, TOXICOLOGICAL, AND CLINICAL STUDIES WILL BE PROPOSED FOR PROMISING CANDIDATE PRODRUGS.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Molecular Design International
Box 41777 Memphis, TN 38174

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No