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Alpha Adrenergic Agonists for CPR

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
25146
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
25146
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MOLECULAR DESIGN INTERNATIONAL, INC.
111 South Highland Street MEMPHIS, TN 38111-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: Alpha Adrenergic Agonists for CPR
Agency: HHS
Contract: 1 R43 HL51716-1,
Award Amount: $72,595.00
 

Abstract:

In the United States alone, approximately 450,000 people yearly suffer a cardiac arrest outsidethe hospital. Less than 10% of these patients are discharged from the hospital alive, and of these,approximately 60% suffer some form of permanent neurologic injury. The poor resuscitation rates andneurologic outcome result in part from the low level of myocardial and cerebral blood flow and oxygendelivery generated during cardiopulmonary resuscitation (CPR). While epinephrine (an alpha 1,2;beta-1,2 adrenergic agonist) is currently used during CPR to enhance perfusion, it is unclear whatspecific adrenergic agonist components are required to optimize hemodynamics and minimize toxicity(i.e. increases on oxygen consumption and ventricular dysrhythmias) in this setting. Our specific aimis to synthesize adrenergic agonists that will maximally enhance myocardial and cerebral hemodynamics,resuscitation rates (without the development of hemodynamically significant ventricular dysrhythmias),and neurologic outcome following resuscitation from cardiac arrest.

Principal Investigator:

William Purcell
9015286050

Business Contact:

Small Business Information at Submission:

Molecular Design
9 Tishomingo Cove Memphis, TN 38111

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No