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Company Information:

Name: Molecular Kinetics Inc
Address: 6201 La Pas Trail
Suite 160
Indianapolis, IN 46268-4869
Located in HUBZone: No
Woman-Owned: Yes
Minority-Owned: Yes
URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,058,784.00 9
SBIR Phase II $1,655,450.00 2

Award List:

BIOINFORMATIC TOOL FOR CANCER PROTEIN ANALYSIS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: A. K. Dunker
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): In the predominant sequence-to-function paradigm, 3-D structure is an obligatory prerequisite for protein function. Even though over 100 counter examples can be found in literature, generalization of the functions associated with non-folded (disordered) protein… More

Cancer drug discovery using disordered protein targets

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: A. K. Dunker
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): A novel technique for cancer drug discovery, "Disordered Protein Phage Display Assay", is proposed. This new technique will inject new avenues to cancer drug discovery methods since disordered proteins are only recently proven to have promising drug-targetable… More

Computational and experimental tool for cancer protein

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: A. K. Dunker
Award Amount: $184,155.00
Abstract:
DESCRIPTION (provided by applicant): In the predominant sequence-to-function paradigm, 3-D structure is an obligatory prerequisite for protein function. Even though over 100 counterexamples can be found in literature, generalization of the functions associated with nonfolded (disordered) protein… More

Tools to accelerate protein structure determination

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: A. K. Dunker
Award Amount: $95,000.00
Abstract:
DESCRIPTION (provided by applicant): Previous work has shown that cancer-associated proteins are rich in intrinsic disorder Given that many of the current techniques used in drug discovery are confounded by disordered protein, new approaches are required The overall goal is to enable the… More

A new cancer protein solubility tool: entropic bristle

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vladimir N. Uversky
Award Amount: $99,511.00
Abstract:
DESCRIPTION (provided by applicant): Expression and purification of cancer-associated proteins are prerequisite steps necessary to study their functions, structures, and interactions. However, these steps are often challenging or even infeasible due to poor protein solubility. Currently, various… More

PI-Fish: A Novel approach for discovering druggable sites in cancer proteins

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Irina Kataeva
Award Amount: $133,509.00
Abstract:
DESCRIPTION (provided by applicant): Project Summary. In the predominant sequence-to-function paradigm, 3-D structure is an obligatory . prerequisite for protein function. This paradigm dominates thinking about drug discovery. Even though over 100 counter examples not following this paradigm are… More

Cardiovascular drug target identification via disordered protein analysis focus

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vladimir N. Uversky
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): A certain type of protein-protein interaction can be blocked using small molecules. This type of interaction involves a disorder-to-order transition of a molecular recognition element on one protein binding to a recept or site on another. Application of our… More

A new cancer protein solubility tool: Entropic Bristle

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vladimir N. Uversky
Award Amount: $750,567.00
Abstract:
DESCRIPTION (provided by applicant): Expression and purification of cancer-associated proteins are prerequisite steps necessary to study their functions, structures, and interactions. However, these steps are often challenging or even infeasible due to poo r protein solubility. This project seeks to… More

A new technology for functional solubilization of kinases

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Protein kinases are highly important enzymes that function primarily as components of signaling pathways, regulating cellular responses such as cell growth, development, differentiation, membrane transport, and cell dea th. Abnormalities in these signaling… More

A new technology for functional solubilization of kinases

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: HHS
Principal Investigator: Carrie H. Croy – 317-280-8737
Award Amount: $904,883.00
Abstract:
DESCRIPTION (provided by applicant): Protein kinases are essential enzymes that function primarily as components of signaling pathways, regulating cellular responses such as division, growth, differentiation, and death. Abnormalities in these signaling pathways can lead to wide- ranging and… More

SBIR Phase I: Tool for cancer protein crystallization based on intrinsically disordered protein

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: NSF
Principal Investigator: Charles R. Kissinger
Award Amount: $146,609.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project will develop the use of unique artificial protein sequences, known as entropic bristles, to accelerate the study of protein structure by the method of X-ray crystallography. Many interesting proteins have proven to be difficult to… More