DESCRIPTION (provided by applicant): In the predominant sequence-to-function paradigm, 3-D structure is an obligatory prerequisite for protein function. Even though over 100 counter examples can be found in literature, generalization of the functions associated with non-folded (disordered) protein… More

DESCRIPTION (provided by applicant): A novel technique for cancer drug discovery, "Disordered Protein Phage Display Assay", is proposed. This new technique will inject new avenues to cancer drug discovery methods since disordered proteins are only recently proven to have promising drug-targetable… More

DESCRIPTION (provided by applicant): In the predominant sequence-to-function paradigm, 3-D structure is an obligatory prerequisite for protein function. Even though over 100 counterexamples can be found in literature, generalization of the functions associated with nonfolded (disordered) protein… More

DESCRIPTION (provided by applicant): Previous work has shown that cancer-associated proteins are rich in intrinsic disorder Given that many of the current techniques used in drug discovery are confounded by disordered protein, new approaches are required The overall goal is to enable the… More

DESCRIPTION (provided by applicant): Expression and purification of cancer-associated proteins are prerequisite steps necessary to study their functions, structures, and interactions. However, these steps are often challenging or even infeasible due to poor protein solubility. Currently, various… More

DESCRIPTION (provided by applicant): Project Summary. In the predominant sequence-to-function paradigm, 3-D structure is an obligatory . prerequisite for protein function. This paradigm dominates thinking about drug discovery. Even though over 100 counter examples not following this paradigm are… More

DESCRIPTION (provided by applicant): A certain type of protein-protein interaction can be blocked using small molecules. This type of interaction involves a disorder-to-order transition of a molecular recognition element on one protein binding to a recept or site on another. Application of our… More

DESCRIPTION (provided by applicant): Expression and purification of cancer-associated proteins are prerequisite steps necessary to study their functions, structures, and interactions. However, these steps are often challenging or even infeasible due to poo r protein solubility. This project seeks to… More

DESCRIPTION (provided by applicant): Protein kinases are highly important enzymes that function primarily as components of signaling pathways, regulating cellular responses such as cell growth, development, differentiation, membrane transport, and cell dea th. Abnormalities in these signaling… More

DESCRIPTION (provided by applicant): Protein kinases are essential enzymes that function primarily as components of signaling pathways, regulating cellular responses such as division, growth, differentiation, and death. Abnormalities in these signaling pathways can lead to wide- ranging and… More