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BIOINFORMATIC TOOL FOR CANCER PROTEIN ANALYSIS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60061
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
CA097629
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Molecular Kinetics Inc
6201 La Pas Trail Suite 160 Indianapolis, IN 46268-4869
View profile »
Woman-Owned: Yes
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: BIOINFORMATIC TOOL FOR CANCER PROTEIN ANALYSIS
Agency: HHS
Contract: 1R43CA097629-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): In the predominant sequence-to-function paradigm, 3-D structure is an obligatory prerequisite for protein function. Even though over 100 counter examples can be found in literature, generalization of the functions associated with non-folded (disordered) protein has been mostly ignored. Applying our proprietary bioinformatics software PONDRs on oncogenes, a large fraction of cancer-associated proteins was found to contain large intrinsically disordered regions crucial to function. Thus, a cancer-specific resource database, Cancer DisProtTM and its companion protocol manual will be developed to incorporate functional disordered data for oncogenes. Using PONDRs, disorder/order predictions will be correlated with functions of a representative set of cancer-associated proteins. Data mining these correlations should reveal relationships between disorder/order state and various protein functions, demonstrating the utility of this approach. Ultimately, Cancer DisProt database will be a compendium of hundreds of cancer-associated proteins with experimentally determined regions of disorder correlated with functions. Cancer DisProt will be a useful bioinformatics tool for functional annotation of entire genomes. The database, augmented with methods for studying counter example proteins, will provide the basis for design of novel approaches to the development of cancer treatments and/or drug discovery.

Principal Investigator:

A. K. Dunker
5093322112
MKINETICS@TURBONET.COM

Business Contact:

Ya-yue Van
5093322112
MKINETICS@TURBONET.COM
Small Business Information at Submission:

MOLECULAR KINETICS, INC.
MOLECULAR KINETICS, INC. 1630 NE LOWER DR PULLMAN, WA 99163

EIN/Tax ID: 911366111
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No