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Automated Parkinson's Disease Dopamine Transporter Scan Analysis Fast Track

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
85911
Program Year/Program:
2007 / STTR
Agency Tracking Number:
NS055475
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Molecular Neuroimaging, L.l.c.
60 TEMPLE STREET, SUITE 8A NEW HAVEN, CT -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2007
Title: Automated Parkinson's Disease Dopamine Transporter Scan Analysis Fast Track
Agency: HHS
Contract: 1R42NS055475-01A2
Award Amount: $840,457.00
 

Abstract:

DESCRIPTION (provided by applicant): We hypothesize that for a class of dopamine transporter SPECT agents, an automated software processing package can be developed, which will objectively yield striatal quantitative uptake values for evaluating Parkinson' s disease (PD) diagnosis and progression. This fully automated and Objective Striatal Analysis (OSA) package will be able to evaluate subjects referred for SPECT neuroreceptor imaging studies with a sensitivity and specificity higher than currently possibl e by visual inspection or manual image processing methods. OSA will carry out (with no user interaction required) the following processing steps: a) reorientation of the reconstructed brain volume along the cantho-meatal line, b) identification of axial sl ices with striatal activity and summation of specified number of slices, c) placement of regional template on left and right caudate and putamen and occipital background region following set rules for movement of regions, d) extraction of count density dat a for determination of regional striatal V3 as indicated in the equation: V3 = (regional striatal count density - occipital count density)/(occipital count density). The required algorithms will be coded into a software package (OSA), and the results of O SA applied to groups of patients and healthy volunteers will be compared to the results obtained by manually analyzing the same subject groups by a highly-trained image processing technologist. We propose to develop a completely automated package f or analysis of presynaptic dopaminergic function in Parkinson's patients which can be easily used in a clinical setting for high quality quantitative imaging assessments of neuroreceptor SPECT brain images. This automated analysis will remove subjectivity in the determination of the imaging outcome measure (progression of disease), and permit a clinical imaging center to obtain accurate diagnostic and monitoring assessments of the patient with reference to a normative dataset.

Principal Investigator:

I. G. Zubal
2034014300
GZUBAL@INDD.ORG

Business Contact:

Jack Mariotti
jmariotti@indd.org
Small Business Information at Submission:

MOLECULAR NEUROIMAGING, LLC
MOLECULAR NEUROIMAGING, LLC 60 TEMPLE STREET, SUITE 8A NEW HAVEN, CT 06510

EIN/Tax ID: 061594851
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
INSTITUTE FOR NEURODEGENERATIV
INSTITUTE FOR NEURODEGENERATIVE
DISORDERS
NEW HAVEN, CT 6510
RI Type: Domestic nonprofit research organization