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In vivo evaluation of a new ligand with picomolar affinity for the serotonin…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
89344
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
MH079568
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Molecular Neuroimaging, L.l.c.
60 TEMPLE STREET, SUITE 8A NEW HAVEN, CT -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: In vivo evaluation of a new ligand with picomolar affinity for the serotonin tran
Agency: HHS
Contract: 1R43MH079568-01A1
Award Amount: $500,000.00
 

Abstract:

DESCRIPTION (provided by applicant): The goal of this research project is to validate in humans a new ligand with picomolar affinity for the serotonin transporter. It will permit quantitative measurement of serotonin transporter (5- HTT) sites in living br ain by imaging with single photon emission tomography (SPECT). The serotonin transporter is known to play a critical role in several physiological and pathophysiological processes, including depression, anxiety, seasonal affective disorder, bulimia, and ps ychosis, as demonstrated by post-mortem data, clinical efficacy of therapies affecting this target site, and imaging studies. A radiotracer that binds specifically to 5-HTT is of great utility in diagnosis, monitoring treatment, and research of these disor ders. There is a need for better tracers that allow quantitation in areas of the brain with low 5-HTT densities such as the cortex.

Principal Investigator:

Gilles D. Tamagnan
2034014309
GTAMAGNAN@INDD.ORG

Business Contact:


jmariotti@indd.org
Small Business Information at Submission:

MOLECULAR NEUROIMAGING, LLC
MOLECULAR NEUROIMAGING, LLC 60 TEMPLE STREET, SUITE 8A NEW HAVEN, CT 06510

EIN/Tax ID: 061594851
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No