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IMPROVED BLOOD SAMPLING AND ANALYSIS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
1528
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
1528
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Moleculon Research Corp
230 Albany St Cambridge, MA 02139
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1986
Title: IMPROVED BLOOD SAMPLING AND ANALYSIS
Agency: HHS
Contract: N/A
Award Amount: $252,000.00
 

Abstract:

THIS PHASE I PROGRAM IS DIRECTED TOWARD ASPECTS OF CLINICAL BLOOD ANALYSIS WHICH HAVE MADE LITTLE PROGRESS IN RECENT YEARS: SAMPLE COLLECTION, PREPARATION, AND COLORIMETRY. MOLECULON WILL SEEK TO INCORPORATE AUTOMATIC MEMBRANE FILTRATION DIRECTLY INTO DISPOSABLE BLOOD SAMPLERS TO OBTAIN CELL-FREE EXTRACTS WITHOUT CENTRIFUGATION, AND WILL INVESTIGATE THE FEASIBILITY OF FURTHER LABOR SAVINGS BASED ON COLORIMETRIC PLASMA ANALYSES CONDUCTED DIRECTLY WITHIN TRANSPARENT MEMBRANES. BOTH THE FILTRATION AND THE THIN FILM COLORIMETRY WILL RELY ON THE UNIQUE PROPERTIES OF POROPLASTIC FILM, A TRANSPARENT PERMSELECTIVE MEMBRANE IN WHICH MANY NORMAL LIQUID-PHASE REACTIONS CAN READILY BE CONDUCTED. TO THE EXTENT THAT PLASMA OBTAINED USING MEMBRANES LACKS THE HIGH MOLECULAR WEIGHT PROTEINS FOUND IN CENTRIFUGED PLASMA, IT SHOULD BE PARTICULARLY SUITABLE FOR ENZYMATIC ANALYSIS OF IMPORTANT LOW MOLECULAR WEIGHT SOLUTES. THE THIN FILM COLORIMETRY TO BE INVESTIGATED WILL NOT RELY ON SEMIQUANTATIVE REFLECTANCE MEASUREMENTS, SUCH AS THOSE USED IN PRESENT HOME GLUCOSE INDICATORS, BUT ON ENZYMATIC SCHEMES IN COMBINATION WITH TRANSMISSION SPECTROMETERS. THE UNDERLYING GOAL OF THE ENTIRE PROGRAM WILL BE TO PROVIDE ACCEPTABLE CLINICAL BLOOD ANALYSES WITH A MUCH REDUCED INVESTMENT OF CLINICAL LABOR. ELIMINATING SAMPLE-HANDLING STEPS SUCH AS THOSE ASSOCIATED WITH CENTRIFUGATION WILL ALSO REMOVE A MAJOR SOURCE OF DANGEROUS LABORATORY ERROR - MISIDENTIFICATION OF SAMPLES DURING POURING OPERATIONS. ANOTHER ASSOCIATED BENEFIT, REDUCTION IN ANALYTIC TURN-AROUND TIMES, COULD ITSELF BE LIFE-SAVING IN CASES SUCH AS SEVERE ELECTROLYTE IMBALANCE OR DIABETIC COMA.

Principal Investigator:

James Davidson
Project Manager
0

Business Contact:

Small Business Information at Submission:

Moleculon Research Corp.
139 Main Street Cambridge, MA 02142

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No