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TAXOL PRODUCTION WITH A NOVEL FERMENTATION REACTOR

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60012
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
CA096455
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Resodyn Corporation
130 North Main Street Suite 600 Butte, MT 59701-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: TAXOL PRODUCTION WITH A NOVEL FERMENTATION REACTOR
Agency: HHS
Contract: 1R43CA096455-01
Award Amount: $135,736.00
 

Abstract:

DESCRIPTION (provided by applicant): The specific innovation proposed for this Phase I project will combine an advanced, novel low-frequency sonic energy technology with the production of fungal secondary metabolites of pharmaceutical importance. The Phase 1 project will demonstrate the use of a novel fermentation reactor to provide improved agitation and aeration during the in vitro cultivation of the endophytic fungus, Penicililum raistrickii, to increase the expression of Taxol. It is proposed to optimize the expression of Taxol by manipulating the fermentation medium and exploiting the unique features of the low frequency sonic technology to ensure effective renewal of the critical medium components to the cell membrane. The impact of the carbohydrate source, nitrogen and phosphate control, addition of pre-cursors, as well as triggers such as yew tree extract and rival fungal extracts, will be investigated. The ultimate objective is a commercially viable route to Taxol based on an optimized strain of Penicillium raistrickii, an optimized fermentation protocol and a high-intensity, low shear fermentation reactor. The overall technical target is to achieve Taxol expression of 10 mg/I.

Principal Investigator:

Todd A. Mcadams
4067232222
TMCADAMS@RESODYN.COM

Business Contact:

Lawrence Farrar
4067232222
ICFARRAR@AOL.COM
Small Business Information at Submission:

MONTEC RESEARCH
MONTEC RESEARCH 1901 S FRANKLIN BUTTE, MT 59701

EIN/Tax ID: 810528815
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No