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Transdermal Delivery of Anti-Malarial Drug

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
73735
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
A043-200-1213
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Resodyn Corporation
130 North Main Street Suite 600 Butte, MT 59701-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Transdermal Delivery of Anti-Malarial Drug
Agency / Branch: DOD / ARMY
Contract: W81XWH-05-C-0050
Award Amount: $70,000.00
 

Abstract:

This Phase I proposal is aimed to develop a technology to delivery lipophilic therapeutic ingredients in broad and antimalarial drug primaquine in specific through skins. The proposed driving force of delivering target drugs is the opposite chemical affiliation of storage copolymer matrix and active therapeutic ingredient. The technology includes the formulation of patches - hydrophilic polymers, selection of permeation enhancers, encapsulation of primaquine in the polymers and drug diffusion flux measurements. The patches will be tested in vitro with cadaver skins for primaquine release or diffusion rate in the Phase I study. In Phase II study, the tests will apply to live animals and human subjects for delivery efficiency evaluation. The key features of the proposed transdermal delivery devices are: ¿ Effective delivery lipophilic anti-malarial drug to the skin ¿ Controllable dosage in the preparation ¿ Enhanced compliance for administration of soldiers ¿ Easy to be carried with soldier and long storage life ¿ Easy and inexpensive to be prepared ¿ Easy to be applied by users The proposed study meets the topic narrative for DOD solicitation A04-200 "Novel Routes of Drug Administration to Enhance Compliance in Soldiers"

Principal Investigator:

Fangxiao Yang
Biochemical Engineer
4067232222
fxyang@resodyn.com

Business Contact:

Lawrence C. Farrar
President
4067232222
lcfarrar@resodyn.com
Small Business Information at Submission:

RESODYN CORP.
1901 South Franklin Butte, MT 59701

EIN/Tax ID: 810528815
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No