DESCRIPTION (provided by applicant): We seek to create an affordable and easily implemented proteomic tool in the form of a low cost "enzyme activity and immunodetection chip" for evaluation of enzyme activities and antigenic determinations at the level of 400 detections per cm2. Specific Aim 1… More

DESCRIPTION (provided by applicant): While genomic and phenotypic analysis has reached a massive scale with the widespread use of DNA chips and arrays, the world of proteomics remains hindered by the complexity of proteins and the difficulty of their analysis. We seek to create an affordable and… More

DESCRIPTION (provided by applicant): Reaction Biology Corporation has developed an extremely low cost nanoliter reaction microarrays to serve markets for ultra high throughput screening (uHTS) drug discovery, large scale IC50 determinations, and large scale IC50 selectivity/toxicity profiling.… More

DESCRIPTION (provided by applicant): Protein kinases play pivotal roles in signal transactions, and dysfunction of them is a key factor for diseases like cancer, inflammation, diabetes etc. Kinome drug discovery is a major focus in pharmaceutical industry, and high throughput screening (HTS) is a… More

DESCRIPTION (provided by applicant): Adverse drug metabolism, drug-drug interactions, and toxicity effects cause numerous drug failures. High throughput screening (HTS) technologies to predict drug toxicity based on chemical structures have the potential to reduce pipeline attrition. Reaction… More

DESCRIPTION (provided by applicant): Reaction Biology Corporation (RBC) has developed an extremely low cost nanoliter reaction microarray to serve various drug discovery needs for high throughput screening (HTS) and compound selectivity profiling. These microarrays can hold more than 6000 individual… More

DESCRIPTION (provided by applicant): High throughput ELISA chip for drug toxicity screening Summary Adverse drug metabolism, drug-drug interactions, and direct toxicity effects have caused numerous drug failures. High throughput biomarker profiling offers the potential to predict drug toxicity to… More

DESCRIPTION (provided by applicant): Chromatin assembly and structure is highly regulated during DNA replication, gene expression, and progression through the cell cycle. Dysfunction of epigenetic factors, including methylation state, are associated with a variety of cancers. Histone lysine… More

DESCRIPTION (provided by applicant): Chemoprotectants for Head-Neck Therapeutics Oral mucositis occurs as a major dose-limiting and complicating side effect of chemotherapy, radiotherapy, or combined chemo/radiotherapy. It is considered the most significa nt complication of head and neck cancer… More

DESCRIPTION (provided by applicant): Chromatin assembly and structure is highly regulated during DNA replication, gene expression, and progression through the cell cycle. Dysfunctions of epigenetic factors, including methylation states, are associated with a variety of cancers. Histone… More

DESCRIPTION (provided by applicant): Chemoprotectants for Head-Neck Therapeutics Oral mucositis occurs as a major dose-limiting and complicating side effect of chemotherapy, radiotherapy, or combined chemo/radiotherapy. It is considered the most significant complication of head and neck cancer… More