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PROSTATE CANCER CHIP

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60094
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
CA097844
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
REACTION BIOLOGY CORPORATION
ONE GREAT VALLEY PARKWAY MALVERN, PA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: PROSTATE CANCER CHIP
Agency: HHS
Contract: 1R43CA097844-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): We seek to create an affordable and easily implemented proteomic tool in the form of a low cost "enzyme activity and immunodetection chip" for evaluation of enzyme activities and antigenic determinations at the level of 400 detections per cm2. Specific Aim 1 will focus on the validation and calibration of enzyme activity chemistries and antigen determination chemistries that are suited for reduction to a chip-based format at the 5 nanoliter scale per reaction. Specific Aim 2 will focus on the development of low cost microfluidics technology for activation of the enzyme/Immuno chips using minimal volumes of biological sample. We seek to conduct 400 detections using 10 to 100 microliters of biological fluid. Specific Aim 3 will focus on the scale down of the chemistries of Aim 1 to a chip based format where each reaction volume is 5 nanoliters and these reactions are activated with test fluids using the microfluidics technology developed in Aim 2. Preliminary studies have demonstrated the feasibility of activating thousands of individual 5 nanoliter reaction centers with a microliter of fluid sample. The Phase I activities will lead toward establishing chip chemistries and microfluidic technologies for a commercialized chip to aid in prostate cancer diagnostics.

Principal Investigator:

Haiching Ma
6107220247
HAICHING@MOREWOODMOLECULAR.COM

Business Contact:

Christophe Sevrain
4126972920
CHRISTOPHE@MOREWOODMOLECULAR.COM
Small Business Information at Submission:

MOREWOOD MOLECULAR SCIENCES, INC
MOREWOOD MOLECULAR SCIENCES, INC 5001 CENTRE AVE PITTSBURGH, PA 15213

EIN/Tax ID: 251889524
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No